Protein Alignment Nek2 and fin1

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_593305.1
• Gene: fin1 / 2542237
• PomBaseID: SPAC19E9.02
• Length: 722
• Species: Schizosaccharomyces pombe
• Alignment Length: 804
• Identity: 196/804 - (24%)
• Similarity: 324/804 - (40%)
• Gaps: 225/804 - (27%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::.|::|..:|:||||..|||:....|.|.|.|.:::..:...:...:..|:::||.|:||||||
pombe     1 MEKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLKHPNIVQ 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCH------ 139
            |....:||.|:.:.:.||.|..||||.::||.:.:::||.|..:.:...||..||..||
pombe    66 YCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRCHYGENAP 130

  Fly   140 -------NKI--PNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSP 195
                   .:|  |..::|||||||||||||...:.|||||||:::|...:.|..|:||||:||||
pombe   131 ACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLLDNTRVFTQSYVGTPYYMSP 195

  Fly   196 ELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAF 260
            |:::...|..||||||:||:::|:|.|..||.||::.:|...|.||..|.....||.|:..:|..
pombe   196 EIIRSSPYSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLIRH 260

  Fly   261 MLAVDHEQRPGIEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELS 325
            .|.|:.:.||....::|.|::....|:|:.:..:|                   |:.|.:|.:..
pombe   261 CLEVNSDLRPTTYQLLRSPILSDIRSKLESERVVL-------------------EQSDLLHKKHQ 306

  Fly   326 STMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAE 390
            ..:                        .|.::|.:                        ||:|..
pombe   307 MLI------------------------QLENDLQF------------------------REQRLS 323

  Fly   391 ERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEE 455
            .|:.||                                   :.|:.:||   ..:|.:|:::||:
pombe   324 ARESEL-----------------------------------ENVIASRL---AQREEILRRELEK 350

  Fly   456 LQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTY--CTIEL 518
             |.|:.:.:. ::.:||:...||             :..:..|:...:..:|...:.:  ||||.
pombe   351 -QLRDMDARY-QRHMQTVVNSMQ-------------KMRVTSPVDHNEQPESSTAEMFVDCTIEA 400

  Fly   519 NETSPT--VAKLN----LATLPAPKSLNTLRKVTFKSP--------------------------- 550
            :: ||.  :.||.    |.||..|....|.::...|.|
pombe   401 SQ-SPLLHIPKLGISKPLQTLSCPGFTLTTQQPILKRPTLRKELSSRALHTTATLMKYRANASSL 464

  Fly   551 ---------------QKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSSNDSGDSQASSTRRKS 600
                           ||   .|..|.....:...::....|..:..|...|...|.:....|:.|
pombe   465 RTTPIDKDGQITSLQQK---NGTSNQVADCMNKLLHTSLDGKKLSPSELCNKFSDGEGLPNRKVS 526

  Fly   601 ILSLFGLSRGSKATS-KSLPSVNQVAQAAATRVQRPPLAVKPPITQEQPAEVPPVANLWTKEQKK 664
            .||:........|:| :|:|:     .:..|..:...:.|.||..|....|.....|:.:.|..|
pombe   527 KLSVESDETAVSASSGESVPT-----DSTLTDTKSKSVFVHPPSPQSLYVEKLEKLNIRSDEVSK 586

  Fly   665 ----------QAFELLAA---MNAAEREASGGGVVGSGPGGARRQH-----------------LR 699
                      .|...||:   ::|.|:.|....:.|:.......||                 .:
pombe   587 PSKASKTLHGYALPSLASPYDVHAEEKIARENEMDGNFKTMKINQHPDEYVLRTPKKIQLLEGQK 651

  Fly   700 QSVRERNSTLQRNRMRRSLVVATG 723
            :|..::...|..|::|||.:...|
pombe   652 RSPVKQLGRLGYNKLRRSAMDNAG 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	111/277 (40%)
fin1	NP_593305.1	STKc_Nek2	3..281	CDD:270857	111/277 (40%)