Protein Alignment Nek2 and Nek11

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_766049.2
• Gene: Nek11 / 208583
• MGIID: 2442276
• Length: 628
• Species: Mus musculus
• Alignment Length: 510
• Identity: 146/510 - (28%)
• Similarity: 220/510 - (43%)
• Gaps: 86/510 - (16%)

  Fly    19 YEVLAVMGNGSFGTCYKVRDKST---GELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            |.:...:|:|||||.|.|.||..   .||...|.::..||:..:......|..:|.:|.||.||:
Mouse    30 YVLQQKLGSGSFGTVYLVSDKKAKPGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVR 94

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            :  |....|.::..|:.|.|.|.||...:|..:...:.|.|..|.....||...:...|.:
Mouse    95 F--HASFMEQETFCIITEYCEGRDLDYRIQEYKEAGKVFAENQIVEWFIQLLLGVDYMHER---- 153

  Fly   146 TILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
            .|||||:|..||||  ..| .|:||||::|:|......|.:..|||||||||.:|.:.||.|||:
Mouse   154 RILHRDLKSKNIFL--KNNLLKIGDFGVSRLLMGSCELATTLTGTPHYMSPEALKHQGYDAKSDI 216

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            |::.|::||||.|...|.|.:|..:...|.:|:...:|..|..:|..|:..||......||....
Mouse   217 WSLACILYEMCCLDHAFAGSSFLSVVLNIVEGKTPSLPDRYPRELNTIMERMLNKSPSLRPSAAD 281

  Fly   275 IIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGV-HPELSSTMFTEQYSFNEG 338
            |::.|.:...:..|..|:|.:        ||         |:::.| ..|.:.|:...|...:..
Mouse   282 ILKAPYMEEQLQLLMCKYPEM--------TL---------EDKNSVCQKEAAHTINAVQKKLHLQ 329

  Fly   339 YGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELAEERRRK 403
            ..| .||.|...||..|..|           :|||.:|          ||| .|..::|||..::
Mouse   330 TLQ-ALSDTQKTTPRERMWL-----------RKLQAAD----------ERA-RRLKKIAEENYKE 371

  Fly   404 KDQEQQ-------------------KRDQELLKEAPSSP--------RALTQNIFD----EVLKT 437
            .|:..|                   :|..|.|.|..|.|        .:|...|.|    |:.:.
Mouse   372 NDKRMQALRSRNVGSVHAHVLHELDERTLESLPEPQSLPCLDLDELEPSLEDTIVDLGHYEIPED 436

  Fly   438 RLHAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQE--KLLQQEKHTCS 490
            .|.|.:....:.....|:.:.:|:|:..:|....|.|.:...  :..||:..|.:
Mouse   437 PLVAEQYYSDVFDSCSEDSEEQEEEMIFSEAGGDTKEEESPSVYRTNQQDSDTAA 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	94/265 (35%)
Nek11	NP_766049.2	STKc_Nek11	29..288	CDD:270861	94/265 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	452..475		6/22 (27%)