Protein Alignment Nek2 and nekl-1

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001293320.1
• Gene: nekl-1 / 189769
• WormBaseID: WBGene00021461
• Length: 983
• Species: Caenorhabditis elegans
• Alignment Length: 690
• Identity: 153/690 - (22%)
• Similarity: 253/690 - (36%)
• Gaps: 192/690 - (27%)

  Fly    19 YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQYYH 83
            ||.:..:|.|:||:....|.:....|...|.:|..:||.::....::|:|:|.:::||||:.||.
 Worm   171 YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYD 235

  Fly    84 HLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTIL 148
            ..  .|...:.|.||...||.|||::.|.::   ..:|..|..::.|:|.|:...|    ..::|
 Worm   236 SF--EEEGVLMIEMEYADGGTLAQMLSRTQN---LLDEEQIGDMMIQMCSAVAYLH----ENSVL 291

  Fly   149 HRDIKPANIFLDAAGNAKLGDFGLARMLRRD--QSFAASFVGTPHYMSPELVKGRKYDRKSDVWA 211
            |||:|.||:||......|:||||:::::..:  ...|.:.||||:|:|||:..|..|:.|||:||
 Worm   292 HRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWA 356

  Fly   212 VGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVII 276
            :||::||||.|:..|.|.....|...|....::.:...||.:::.:|..:|.:|.::||
 Worm   357 LGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRP------ 415

  Fly   277 RHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQYSFNEGYGQ 341
                                       :.|...::....|..  |...|.:| ....||...|..
 Worm   416 ---------------------------SAPQALKMLRPSENR--HRHTSGSM-RSSVSFTTLYDL 450

  Fly   342 RRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELAEERRRKKDQ 406
            ...::|....|||.|                               |...:||.|:     |...
 Worm   451 HVPTITLSSIPDLPS-------------------------------RISIKQVALS-----KTHT 479

  Fly   407 EQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQT------------- 458
            .....|.||.....:|...|....|.::...||     .|||..:.::.:..
 Worm   480 MVLTNDNELFGFGDNSCGQLGFGKFSKMENGRL-----VESLKGRDIQSVGVGNYFSVICCDRGT 539

  Fly   459 -----REQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHDDTYCTIEL 518
                 ..:.|.|.:....:.:..:.|:||::......|                .||.....:|.
 Worm   540 LLTFGTAKNLGLGKDAKDSAKPMLLEQLLRENIKDIYC----------------GHDHVVAVLES 588

  Fly   519 NET----SPTVAKLNLATL---------PAPKS-------------------------------- 538
            .|.    |....:|.|.||         |.|.:
 Worm   589 GECLGWGSNQYGQLGLPTLEHFFAPTKIPMPSNKKIVYGKAGKDATMLLSDDGSLIAMGSNKHNK 653

  Fly   539 LNTLRKVTF-----KSPQKFVTYG--IENMPPPAVKPAVNPPPTGVPMQ----MSVSSNDSGDSQ 592
            ||..::|.|     |:|..:|...  ::..|...|..:|....:||.::    |....||:.:
 Worm   654 LNLTQRVGFFTKEKKTPNDYVNKPTILQGFPERVVDFSVGSYHSGVILESGQVMIFGRNDNTE-- 716

  Fly   593 ASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRV 632
                        .||....|...:.:..|..:...|.|.|
 Worm   717 ------------LGLGNSQKMAVRCVKPVKSLLHHACTHV 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	85/263 (32%)
nekl-1	NP_001293320.1	STKc_Nek	170..423	CDD:270855	86/293 (29%)
		ATS1	471..>765	CDD:444065	54/314 (17%)