Protein Alignment Nek2 and Nek1

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001280566.1
• Gene: Nek1 / 18004
• MGIID: 97303
• Length: 1275
• Species: Mus musculus
• Alignment Length: 777
• Identity: 197/777 - (25%)
• Similarity: 293/777 - (37%)
• Gaps: 209/777 - (26%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::.|..|..:|.||||....|:....|..:..|.:|...:.:.:......|::||..::||||||
Mouse     1 MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQ 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR-QRFEEPYIWRVLFQLCRALQVCHNKIPN 144
            |....  .|..|:||||:.|.||||   .:|..:|: ..|:|..|.....|:|.||:..|::
Mouse    66 YKESF--EENGSLYIVMDYCEGGDL---FKRINAQKGALFQEDQILDWFVQICLALKHVHDR--- 122

  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             .|||||||..||||...|..:|||||:||:|......|.:.:|||:|:|||:.:.:.|:.|||:
Mouse   123 -KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDI 186

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            ||:||::||:|.|:..|.......|..||..|.|..:...||.||:.:::.:...:...||.:..
Mouse   187 WALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNS 251

  Fly   275 IIRHPLVVRNISELDGKF--PILVDSGEDF----------YTLPSGARLFEDEEEDGVHPELSST 327
            |:....:.:.|.    ||  |.|:  .|:|          ..|| |.|....:......|....|
Mouse   252 ILEKGFIAKRIE----KFLSPQLI--AEEFCLKTLSKFGPQPLP-GKRPASGQGVSSFVPAQKIT 309

  Fly   328 MFTEQYSF---NEGYGQRRLSVTGVFTPDLRSELFYSAKRK---IFPAKKLQLSDPSLYESIRRE 386
            ....:|..   .:.||.::|           .|.....|.|   ..|.||:...:.....|   |
Mouse   310 KPAAKYGVPLTYKKYGDKKL-----------LEKKPPPKHKQAHQIPVKKMNSGEERKKMS---E 360

  Fly   387 ERAEERQVELAEERRRKKDQ------EQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAI-RA 444
            |.|::|::|..|:.:::|||      ||.||.:                      |.||..| ||
Mouse   361 EAAKKRRLEFIEKEKKQKDQIRFLKAEQMKRQE----------------------KQRLERINRA 403

  Fly   445 QESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAP-PIPPRKPAKSH 508
            :|...:..|....:.|.:...                       ......::| |..||...:.:
Mouse   404 REQGWRNVLRAGGSGEVKASF-----------------------FGIGGAVSPSPCSPRGQYEHY 445

  Fly   509 H---DDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAV 570
            |   |                           .:..||....::..|...|| ..:|...|.|.|
Mouse   446 HAIFD---------------------------QMQRLRAEDNEARWKGGIYG-RWLPERGVPPGV 482

  Fly   571 NPPPTGVPMQMS--VSSNDSGDSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQ 633
            .|   |.|.:.|  ..|.|:|                       |..|:|..:..|::.|:|..|
Mouse   483 RP---GFPSEASGHYHSPDAG-----------------------AIRKTLKRLKAVSKQASTNRQ 521

  Fly   634 RPPLAVKPPITQEQPAEVPPVANLWTKEQKKQAFELL-----AAMNAAERE----------ASGG 683
            :..|||                     |:..|..|.|     |..|.|..|          :..|
Mouse   522 KGHLAV---------------------ERANQVEEFLQRKREAMQNKARAEGHVGLLQNLASLYG 565

  Fly   684 GVVGSGPGG-----------ARRQHLR-QSVRERNSTLQRNRMRRSLVVATGHQKLTTRDQM 733
            |...|..||           ||.:.:| |:..||.....:.|........|..|:.|....|
Mouse   566 GRPSSSRGGKPRNNEEEVYLARLRQIRLQNFNERQQIKAKLRGENKEADGTKGQEATEETDM 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/263 (36%)
Nek1	NP_001280566.1	STKc_Nek1	3..258	CDD:270858	95/263 (36%)