DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nek2 and glo-4

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_505392.3	Gene:	glo-4 / 179306	WormBaseID:	WBGene00017195	Length:	1386	Species:	Caenorhabditis elegans

Alignment Length:	612	Identity:	111/612 - (18%)
Similarity:	193/612 - (31%)	Gaps:	212/612 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 STGELFAWKGMNYDELDEAKCDALVS-EISVLRQL--QHPNIVQ----YYHHLVNREAKSVYIVM 97
            |:|:|.||.|..:     .:|....| .|:.|.|:  ..|.|.:    .:|        |.:|
Worm   787 SSGQLSAWGGNRF-----GQCGVGHSFRIANLHQVDGDWPAIEKIACGQFH--------SAFI-- 836

  Fly    98 ECCAGGDL--------AQIVQRARSQRQRFEEPYIWRVLFQLCRALQV----CHNKI--PNGTIL 148
              |:.|.|        .|:....|:...:....   ||...:|:..|:    .|..:  ..|.:|
Worm   837 --CSDGSLWTFGWGVWGQLGHGGRNNSNQLVPT---RVNGLICKVTQIACGRAHTVVLTDTGRVL 896

  Fly   149 HRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVG 213
                        ..|:...|..|:      |......|..||..:.|..|:    |..:..:...
Worm   897 ------------VCGSGSYGQMGV------DDDIKKVFAFTPLPLGPLRVR----DIATHYYHSI 939

  Fly   214 CL-----VYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIE 273
            |:     |:|........:.|.|.....:.||.:.:..|:..|..           .:...|.:.
Worm   940 CITEDNRVFEWGRNPQELKMRMFVMKKIRSAQLKNTEDPSSPSPS-----------TNGSTPRVN 993

  Fly   274 V-----IIRHPLVVRNISE-LDGKF---------PILVDSGEDFYTLPSGA-------------- 309
            :     |.|..|.:|.:.. |||..         ..|:.|....||...|.
Worm   994 LNLPAEIPREDLGLREVKHFLDGNIVSVACGLSHSALITSEGTLYTWGKGLDYQLGHGNKNERME 1058

  Fly   310 --RLFEDEEEDGVHPELSSTMFTEQYSFNEG----YGQRRLSVTGVFT------PDLRSELFYSA 362
              ::||......|:..|.:.....  |.::|    :|:......||.|      .|:..:.|:.|
Worm  1059 PHQVFEPNGAKWVNVSLGNNHTIA--STDDGSVFAWGKNDFGQCGVLTKKNGNSADVTKKFFFQA 1121

  Fly   363 K--RKIFP-----------------------------------AKKLQLSDPSLYESIRR----- 385
            :  |:..|                                   ..:|:.||.::.:::.:
Worm  1122 RDGRRFMPNVDESQFVQKPGLIPDVRVRNLNEDGNEGVDKEEIVDRLKASDVNVVQAVSKHLYSP 1186

  Fly   386 -EERAEERQVELAEERRRKKDQEQQKRDQELLKEAP-SSPRALTQNIFDEVLKT--RLHAIRAQE 446
             |.:.....:|  :|.|..|.|:|.|.|.|   :.| .:..||...|..:|.:.  .:..::...
Worm  1187 IEGKCNGSIIE--DEPRNGKIQKQNKYDGE---DGPLCTTTALVHLIAGDVKRAIRMIEWLKTDS 1246

  Fly   447 SLLQQKL--------------EELQTRE-------------------QELQL-----AEQRVQTL 473
            |..::.|              |::|:||                   |..||     .::|||:
Worm  1247 STCEKSLMVLSSLVWEVMANHEDVQSREALSAAFRHVPMSDSMRKGKQIAQLWPAVWNDERVQS- 1310

  Fly   474 ERQMQEKLLQQEKHTCSCRQPIAPPIP 500
            ...:.||:...:..|.:.:....|.||
Worm  1311 SLSIDEKIAMLDGFTSASKPVSCPTIP 1337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	50/271 (18%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	50/271 (18%)
glo-4	NP_505392.3	RCC1_2	773..801	CDD:290274	6/18 (33%)
		RCC1_2	823..852	CDD:290274	7/40 (18%)
		RCC1	839..889	CDD:278826	9/52 (17%)
		RCC1_2	876..905	CDD:290274	5/40 (13%)
		RCC1	893..941	CDD:278826	12/69 (17%)
		RCC1_2	1018..1047	CDD:290274	5/28 (18%)
		RCC1	1034..1082	CDD:278826	7/47 (15%)
		RCC1_2	1070..1099	CDD:290274	5/30 (17%)
		VAD1-2	1303..>1371	CDD:291956	9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010