DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and herc-1

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_490834.1	Gene:	herc-1 / 171700	WormBaseID:	WBGene00021685	Length:	1019	Species:	Caenorhabditis elegans

Alignment Length:	258	Identity:	53/258 - (20%)
Similarity:	89/258 - (34%)	Gaps:	86/258 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LQHPNIVQYYHHLVNREAKSVYIVMECCAGGD--LAQIVQRARSQRQRFEEPYIWRVLFQLCRAL 135
            :|..:::...:|::..|   .:.:.|.....|  |..:::..|....:.|..|.....|.|
Worm   570 MQKLSLINKTYHIIPLE---TFYIDELNTSVDLKLEYVLELTRQDPNKTELDYWTHFPFLL---- 627

  Fly   136 QVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKG 200
                |.:..|.:         ||::|         .|.:.|||.    :|...|.|
Worm   628 ----NGVAKGEL---------IFVEA---------WLMQTLRRQ----SSLFNTAH--------- 657

  Fly   201 RKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLA-V 264
                        |.:::|:..|....|       .|.|.....:::..:..:|||:.:...:| .
Worm   658 ------------GTIIFELPHLELTVR-------REFIVSDTMNQMAGLSESDLQKPLKVNIAGE 703

  Fly   265 DHEQRPGI--EVIIRHPLVVRNISELD-GKFPILVDSGED-------FYTLPSGARLFEDEEE 317
            |.:...|:  |..|   ||:|.|.:.| |.|      .||       |..|||.   |.|.|:
Worm   704 DADDAGGVRKEFFI---LVMRKILQSDYGMF------SEDEESHLVWFSGLPSE---FCDREQ 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	37/212 (17%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	37/212 (17%)
herc-1	NP_490834.1	ATS1	2..359	CDD:227511
herc-1	NP_490834.1	HECTc	667..1016	CDD:238033	28/107 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010