DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and nek8

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_620776.1	Gene:	nek8 / 171094	ZFINID:	ZDB-GENE-020509-1	Length:	697	Species:	Danio rerio

Alignment Length:	274	Identity:	98/274 - (35%)
Similarity:	156/274 - (56%)	Gaps:	10/274 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::.||...|:|.|:||..:..|.::...|...|.:..:::...:..|..:|..||:.|.||||::
Zfish     1 MEKYEKTKVVGRGAFGIVHLCRRRTDSALVILKEIPVEQMTRDERLAAQNECQVLKLLSHPNIIE 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            ||.:.:  |.|::.|.||...||.||..:|:..:  ...:|..|.....|:..||...|||:
Zfish    66 YYENFL--EDKALMIAMEYAPGGTLADYIQKRCN--SLLDEDTILHSFVQILLALYHVHNKL--- 123

  Fly   146 TILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             |||||:|..||.||.... .|:||||::::| ..:|.|.:.||||.|:||||.:|:.|::|||:
Zfish   124 -ILHRDLKTQNILLDKHQMIVKIGDFGISKIL-VSKSKAYTVVGTPCYISPELCEGKPYNQKSDI 186

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            ||:||::||:.:|:..|.......|..||..|.|:.|...||.:|:::|..||.:|..:||.:..
Zfish   187 WALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLILNMLNLDPSKRPQLNE 251

  Fly   275 IIRHPLVVRNISEL 288
            |:.|.:.:|.:..|
Zfish   252 IMAHAICIRPLLNL 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	96/263 (37%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	96/262 (37%)
nek8	NP_620776.1	STKc_Nek8	3..258	CDD:270859	96/263 (37%)
		S_TKc	4..255	CDD:214567	95/259 (37%)
		ATS1	309..662	CDD:227511
		RCC1 1	417..468
		RCC1 2	469..520
		RCC1 3	521..586
		RCC1 4	587..636
		RCC1 5	637..689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950