DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and NEK10

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001381899.1	Gene:	NEK10 / 152110	HGNCID:	18592	Length:	1172	Species:	Homo sapiens

Alignment Length:	663	Identity:	169/663 - (25%)
Similarity:	283/663 - (42%)	Gaps:	141/663 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNY-------DELD-EAKCDALVSEISVL 70
            |.:.:|.:|..:|:|:||..||||..|...|.|.|.:|.       |:.| ::....:|||::::
Human   514 KYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTII 578

  Fly    71 R-QLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRA 134
            : ||.|||||:||...:  |...:|||||...|..|.:.....:.:...|.|..:|::..|||.|
Human   579 KEQLYHPNIVRYYKTFL--ENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLA 641

  Fly   135 LQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVK 199
            |:..|.:   ..|:|||:.|.||.|.......:.|||||:. :::.|...|.|||..|..||::|
Human   642 LRYLHKE---KRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQ-KQENSKLTSVVGTILYSCPEVLK 702

  Fly   200 GRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIP-AIYSTDLQEIIAFMLA 263
            ...|..|:|||||||::|:|..|.|||.......|:.||.:..:..:| .|||..:.:.|:..|.
Human   703 SEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLT 767

  Fly   264 VDHEQRPGI--------EVIIRHPLVVRNIS----ELDGKFPILVDSGEDFYTLPSGARLFEDEE 316
            .|.|.||.|        :|::::   :.|:|    .|:.|.     ..|...|    .|.|.:..
Human   768 PDAEARPDIVEVSSMISDVMMKY---LDNLSTSQLSLEKKL-----ERERRRT----QRYFMEAN 820

  Fly   317 EDGV--HPELSSTMFTEQYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQ------ 373
            .:.|  |.||:...       :|.:.:..||.:......|:|||..||.   .|.:..|
Human   821 RNTVTCHHELAVLS-------HETFEKASLSSSSSGAASLKSELSESAD---LPPEGFQASYGKD 875

  Fly   374 --------LSDPSL-YESIRREERAE-ERQVELAEERRRKKDQ-------------------EQQ 409
                    |||.:. .|:..::..:| :.::::::........                   |:|
Human   876 EDRACDEILSDDNFNLENAEKDTYSEVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQ 940

  Fly   410 KRDQELLKEAPSSPR-ALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQE----------- 462
            .:.::......|.|| ||..  .|.:||...|.:||.   :::...||.|..|.
Human   941 SQTRDFTGGTGSRPRPALLP--LDLLLKVPPHMLRAH---IKEIEAELVTGWQSHSLPAVILRNL 1000

  Fly   463 -----------------LQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKSHHD 510
                             :.:::::|:.:...:|:.|:|..|.....:.|         || .||:
Human  1001 KDHGPQMGTFLWQASAGIAVSQRKVRQISDPIQQILIQLHKIIYITQLP---------PA-LHHN 1055

  Fly   511 DTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQ----KFVTYGIENMPPPAVKPAVN 571
            .....||..:.|....:.|...|.     :.::|::..||:    .|.|.....:...:...:::
Human  1056 LKRRVIERFKKSLFSQQSNPCNLK-----SEIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLS 1115

  Fly   572 P-PPTGVPMQMSV 583
            | .|||:|..:.:
Human  1116 PNDPTGLPTSIEL 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	98/280 (35%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	98/279 (35%)
NEK10	NP_001381899.1	ARM	209..251
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..875		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..954		4/55 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910