DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nek2 and Herc2

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001347009.1	Gene:	Herc2 / 15204	MGIID:	103234	Length:	4836	Species:	Mus musculus

Alignment Length:	649	Identity:	122/649 - (18%)
Similarity:	208/649 - (32%)	Gaps:	211/649 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 HNKIPNGTIL-------HR----DIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAAS-FVGTPH 191
            |...|.||.:       ||    |...|  ||.|..:..:.|:.:...|.:.:.:... .:.||.
Mouse  1364 HCSSPGGTPISKSRLCSHRWALGDHSQA--FLQAIADNNIQDYNVKDFLCQIERYCRQCHLTTPI 1426

  Fly   192 YMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQE 256
            ...||          ..|..||.|:  :|.|                          :...||..
Mouse  1427 TFPPE----------HPVEEVGRLL--LCCL--------------------------LKHEDLGH 1453

  Fly   257 IIAFMLAVDHEQRPGIEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDG-V 320
            :   .|::.|....|||. ::|..:.:::          ||.....|  .:...|.:..:|.| .
Mouse  1454 V---ALSLVHVGTLGIEQ-VKHRTLPKSV----------VDVCRVVY--QAKCSLIKTHQEQGRS 1502

  Fly   321 HPELSSTMFTE-QYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIR 384
            :.|:.:.:... ::.|||            ..|.:.|:|...:|.|             |..|:.
Mouse  1503 YKEVCAPVIERLRFLFNE------------LRPAVCSDLSIMSKFK-------------LLGSLP 1542

  Fly   385 REERAEERQVELAEERRRKK--------DQEQQKRDQE-------LLKEAP----------SSPR 424
            |..|..::   :..|||:|:        |.|::..::|       :|..:|          .||:
Mouse  1543 RWRRIAQK---IIRERRKKRVPKKPESIDSEEKIGNEESDLEEACVLPHSPINVDKRPISMKSPK 1604

  Fly   425 ALTQNIFDEV--------LKTRLHAIRAQESLLQQKLEELQTRE------------QELQLAEQR 469
            ...|.:.:.|        ||..:..:..|.:||...:|.....|            ::|:.||.|
Mouse  1605 DKWQPLLNTVTGVHKYKWLKQNVQGLYPQSALLNTIVEFALKEEPVDVEKMRKCLLKQLERAEVR 1669

  Fly   470 VQ----TLERQMQEKLLQQEKHT--CSCRQPIAPPIPPRKPAKSHHDDTYCTIELNETSP----- 523
            ::    .|:...:..||...::.  |..::.|...|...:|.      |.|..:::...|
Mouse  1670 LEGIDTILKLAAKSFLLPSVQYAMFCGWQRLIPEGIDIGEPL------TDCLRDVDLIPPFNRML 1728

  Fly   524 ---TVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNPPPTGVPMQMSVSS 585
               |..||      ...::..:|.|...:..:|...||:                .||:|...:.
Mouse  1729 LEVTFGKL------YAWAVQNIRSVLMDASARFKELGIQ----------------PVPLQTITNE 1771

  Fly   586 NDSGDSQASSTRRKSI---LSLFGLSRGSKATSKSLPSVNQVAQAAATRVQRPPL---------- 637
            |.:|.|..:..:.:.:   ||:..|..|:......|.|........|.|:..|..
Mouse  1772 NPAGPSLGTIPQARFLLVMLSMLTLQHGANNLDLLLNSGTLALTQTALRLIGPTCDSVEDDMNAS 1836

  Fly   638 --AVKPPITQEQPAEVPPVANLWTKEQKKQAFELLAAMNAAEREASG-----GGVVGSGPGGAR 694
              .....:.:|...|..||      :......||.|.|....|...|     |...|..||..|
Mouse  1837 ARGASATVLEETRKETAPV------QLPVSGPELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGR 1894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	31/153 (20%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	31/153 (20%)
Herc2	NP_001347009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..90
		RCC1 1-1	416..462
		RCC1 1-2	463..513
		ATS1	<494..787	CDD:227511
		RCC1 1-3	514..569
		RCC1 1-4	570..621
		RCC1 1-5	624..675
		RCC1 1-6	676..727
		RCC1 1-7	729..779
		Cyt-b5	1212..1283	CDD:365921
		MIB_HERC2	1871..1930	CDD:369043	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2351..2376
		UBA_HERC2	2461..2508	CDD:270585
		Cul7	2555..2632	CDD:371573
		SH3_15	2640..2697	CDD:375773
		ZZ_HERC2	2707..2751	CDD:239084
		APC10-HERC2	2766..2911	CDD:176485
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2928..2947
		ATS1	2957..3323	CDD:227511
		RCC1 2-1	2959..3010
		RCC1 2-2	3011..3065
		RCC1 2-3	3066..3117
		RCC1 2-4	3119..3169
		RCC1 2-5	3172..3223
		RCC1 2-6	3225..3275
		RCC1 2-7	3276..3327
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3479..3499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3517..3537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3604..3632
		RCC1 3-1	3953..4004
		RCC1 3-2	4006..4058
		ATS1	4025..4330	CDD:227511
		RCC1 3-3	4060..4110
		RCC1 3-4	4112..4164
		RCC1 3-5	4166..4216
		RCC1 3-6	4218..4268
		RCC1 3-7	4270..4320
		HECTc	4423..4794	CDD:238033
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4806..4836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010