DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and RCC1

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001041659.1	Gene:	RCC1 / 1104	HGNCID:	1913	Length:	452	Species:	Homo sapiens

Alignment Length:	313	Identity:	64/313 - (20%)
Similarity:	109/313 - (34%)	Gaps:	67/313 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GELFAWKGMNYDE-----LDEAKCDALVSEISVLRQLQHP--NIVQYYHHLVNREAKSVYIVMEC 99
            |.:|.|.....:.     |:..|    .|.:.|..||..|  .:.....|||...|......:.|
Human   169 GRVFLWGSFRDNNGVIGLLEPMK----KSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGC 229

  Fly   100 CAGGDLAQIVQ--RARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAA 162
            ...|.|.::.:  ..|..||..|     |:|...|..|:   ::...|.:..:|......|..|.
Human   230 GEQGQLGRVPELFANRGGRQGLE-----RLLVPKCVMLK---SRGSRGHVRFQDAFCGAYFTFAI 286

  Fly   163 GN-AKLGDFGLARMLRRDQSFAASFVGTPHYMS---PELVKGRKYDRKSDVWAVGCLVYEMCALR 223
            .: ..:..|||:...:         :|||...|   |:.:...|...||.|...|...:.:|.
Human   287 SHEGHVYGFGLSNYHQ---------LGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCM-- 340

  Fly   224 PPFRGRAF-------------DQLSEKIAQGEFSRIPAIYS-----------TDLQEIIAFMLAV 264
             ...|:|:             :...||......||:||:.|           |....:.|:.:..
Human   341 -DSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGT 404

  Fly   265 DHEQRPGIEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEE 317
            :::...|.:.....|:.:.. .:|:.:..:.|.||.....|     |.:|:|:
Human   405 NYQLGTGQDEDAWSPVEMMG-KQLENRVVLSVSSGGQHTVL-----LVKDKEQ 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	56/275 (20%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	56/275 (20%)
RCC1	NP_001041659.1	RCC1	66..113	CDD:278826
		RCC1	116..165	CDD:278826
		RCC1	168..218	CDD:278826	13/52 (25%)
		RCC1	221..286	CDD:278826	14/72 (19%)
		RCC1	289..340	CDD:278826	13/59 (22%)
		RCC1	343..386	CDD:278826	9/42 (21%)
		RCC1	394..445	CDD:278826	8/56 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010