Protein Alignment Nek2 and nek5

DIOPT Version :9

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_002936777.2
• Gene: nek5 / 100497645
• XenbaseID: XB-GENE-1012494
• Length: 931
• Species: Xenopus tropicalis
• Alignment Length: 702
• Identity: 169/702 - (24%)
• Similarity: 283/702 - (40%)
• Gaps: 182/702 - (25%)

  Fly    13 QKTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPN 77
            |.|:..|:::.::|.|:||..|..:.||.......|.:|..::...:.:|...|:.:|.:::|||
 Frog     3 QSTMDKYDIVRMIGEGAFGKAYLAKGKSDNMQCVIKEINLSKMPTKEKEASHKEVVLLAKMKHPN 67

  Fly    78 IVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKI 142
            ||.::..:  .|...:|||||.|.||||.:.|.:.|.  ..|||..|.....|:...|:..|::
 Frog    68 IVTFFSSI--EERNKLYIVMEYCDGGDLMKRVNKQRG--VLFEEDQILSWFVQISLGLKHIHDR- 127

  Fly   143 PNGTILHRDIKPANIFLDAAGN-AKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRK 206
               .:||||||..||||...|. |||||||:||||......|.:.||||:|:|||:.:.:.|:.|
 Frog   128 ---KVLHRDIKAQNIFLSNNGTLAKLGDFGIARMLNNTMELARTCVGTPYYLSPEICENKPYNNK 189

  Fly   207 SDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPG 271
            :|:|::||::||:|||:.||...:..||..||.:|.:..||..||.||:.:::.:..:....||.
 Frog   190 TDIWSLGCVLYELCALKHPFEASSLRQLVLKICRGRYEPIPTKYSYDLRILVSQLFKISSRDRPS 254

  Fly   272 IEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQYSFN 336
            |..|::.|.:.:.|::                                   .||..:..|::|..
 Frog   255 INSILKKPFLEKRINK-----------------------------------HLSPELIEEEFSHT 284

  Fly   337 EGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELAEERR 401
            ..:.::..|          :...|..|.|..|..|::         :.:.||.:.|:|     ..
 Frog   285 VIHRKKPSS----------NPARYPCKPKQLPVAKVE---------VAKAERCKIREV-----NS 325

  Fly   402 RKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAI------------RAQESLLQ---- 450
            .|.....|.|.:.|.|.....|.::.|.          ||:            ||..:.:|
 Frog   326 PKPKVAVQPRREVLPKRNEWKPPSVPQQ----------HAVKKYWEPKPDVGGRAAVAKIQGQYD 380

  Fly   451 ---QKLEELQTREQE-----LQLAEQRVQTLERQMQEKLLQQEKHTCSCRQPIAPPIPPRKPAKS 507
               .:|..:|.|..|     :....|||:...:|.                           |..
 Frog   381 HYFAQLNNIQRRGYEQMPNNVPHVNQRVEDYYKQR---------------------------AMQ 418

  Fly   508 HHDDTYCTIELNETSPTVAKLNLATLPAPKSLN----TLRKVTFKSPQKFVTYGIENMPPPAVKP 568
            |.:.                     |||...|.    .|.|:..:..........::...||.:|
 Frog   419 HQNQ---------------------LPADYLLRRQEAQLYKLKVEKQMGLRPSSADHFYKPASRP 462

  Fly   569 AVNP--PPTGVPMQMSVSSNDSGDSQASSTRRKSILSLFGL--------SRGSKATS---KSLPS 620
            |::|  ....:|.:..:.:|::        |.:..|....|        .||:||.:   :..|.
 Frog   463 ALSPEVQMNRLPQKQQIRNNEN--------REQEYLKQLELIRQQYHNDVRGNKAKAGLQQEAPR 519

  Fly   621 V---NQVAQAAATRVQRPPLAVKPPITQEQPAEVPPVANLWTKEQKKQAFEL 669
            :   ..:.|....:::.|  .|:|  ..::|||.....|...|:.:::..||
 Frog   520 LVEGTYLVQQGGHKLEGP--CVQP--DSKEPAEEIQCLNQILKQNREERREL 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	98/263 (37%)
		S_TKc	19..281	CDD:214567	98/262 (37%)
nek5	XP_002936777.2	PKc_like	8..264	CDD:389743	98/263 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920