DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and herc3

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_002938676.3	Gene:	herc3 / 100488790	XenbaseID:	XB-GENE-968537	Length:	1050	Species:	Xenopus tropicalis

Alignment Length:	338	Identity:	62/338 - (18%)
Similarity:	111/338 - (32%)	Gaps:	113/338 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GEESAGMDFSQKTLQDYEVLAVMGN----------------GSFGTCYKVRDKSTGELFAWKGMN 51
            |....|.|.....:....||.:||:                .|.||.|.......|:|    |..
Frog   270 GSGQLGHDSLNNEINPRRVLELMGSEVSQIACGRQHTLAFVPSSGTLYAFGCGDLGQL----GTG 330

  Fly    52 YDELDEAKCDALV--------SEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQI 108
            :.  :..||.|:|        .:||:     |.:...|            .||.:..:||:...:
Frog   331 HK--NNVKCPAVVKGKWAAHSGQISM-----HADRAAY------------NIVKQIFSGGNKTFV 376

  Fly   109 VQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLA 173
            :.......|..::       |:.|.  |..|..:.|...:  |:....:..::..|:.   .|:.
Frog   377 LCSKLESSQPADD-------FRFCS--QRNHTSVINEETI--DVWRQKVLENSNTNSM---NGIV 427

  Fly   174 RMLRRDQSFAASFV---GTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLS 235
            :.|.....:..||:   ...|:.:...:.|                ..||:::..|
Frog   428 QTLSSLACWNGSFLEKRNDEHFRTSPKIPG----------------INMCSIKVLF--------- 467

  Fly   236 EKIAQGEFSRIPAIYSTDLQEII----AFMLAVDHEQRPGIEVIIRHPLVVRNISELDGKFPILV 296
            ||:.....||:       |::|:    :|::.......|.:|.:        .|..:..:||:|.
Frog   468 EKLMNVHHSRL-------LEQILKGFESFLIPQLSSSPPDVEAM--------RIYIILPEFPLLQ 517

  Fly   297 DSGEDFY---TLP 306
            ||  .:|   |||
Frog   518 DS--KYYITLTLP 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	49/293 (17%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	49/292 (17%)
herc3	XP_002938676.3	RCC1	3..49	CDD:395335
		ATS1	44..353	CDD:227511	18/88 (20%)
		HECTc	702..1048	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010