DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and LOC100486333

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_002936837.2	Gene:	LOC100486333 / 100486333	-ID:	-	Length:	494	Species:	Xenopus tropicalis

Alignment Length:	481	Identity:	127/481 - (26%)
Similarity:	223/481 - (46%)	Gaps:	60/481 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAK-CDALVSEISVLRQLQHPNIV 79
            ::.||.:..:|.|:....:.:|:|.|.:.:|.|.:..||....: .::::.|.::|.:|.||::|
Frog     1 MEKYEKILKIGRGATAEVFLMRNKETKKNYAVKKIKIDESKRLRNKESILQEATILGKLVHPHVV 65

  Fly    80 QYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQR----FEEPYIWRVLFQLCRALQVCHN 140
            ..:..:.:.|.:.::||.:.|.||.|...:      :||    |.|..|.....||..|:|..|:
Frog    66 ACHECICDEEDEHIFIVQDYCDGGTLDDHI------KQRNGALFPEDTIMDWFIQLTMAVQYIHS 124

  Fly   141 KIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDR 205
            .    .|||||||.:|:||...|..:|||||::::|......|::.||||:|:||||.:...|..
Frog   125 M----KILHRDIKTSNVFLTKKGMVRLGDFGISKVLSSTMDMASTCVGTPYYLSPELCQDIPYSS 185

  Fly   206 KSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRP 270
            |||:||:|||:||||||:|.|.......|..||.:||:..|...||.||.:::..:|....|.||
Frog   186 KSDIWALGCLLYEMCALQPAFNAANLISLFFKIVKGEYPPISDCYSIDLHKLVKTILDKCPESRP 250

  Fly   271 GIEVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFED--EEEDGVHPE--LSSTMFTE 331
            ....|:       |:|.:..:..:.:...|        ::|:..  .:::...|:  .|.|....
Frog   251 SASCIL-------NLSFVQEQLKLFIQKHE--------SQLYRQTASKKENTSPQENRSKTSVGH 300

  Fly   332 QYSFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKL-QLSDPSLYESIRREERAEERQVE 395
            ..:..:.: :.:.:..|.:.||:       .|.:::..::| ...|.|.|.    |:..:...|.
Frog   301 HDTAKDNF-RPKSAPPGPYKPDV-------TKCELWDQEELSSTGDKSEYS----EDFDDNESVS 353

  Fly   396 LAEERRRKKD----------QEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQ 450
            ..||....::          :|....|.|...|.|.....:..|..:.|:.   ||..|.|....
Frog   354 SVEENLEGENGTPCENEDIPEEIDLVDDEGESEYPDDFEEVEGNTLEMVVS---HARSAMEVEAD 415

  Fly   451 QKLEELQTREQELQLAEQRVQTLERQ 476
            .:..:....:|:.|.....::|:.:|
Frog   416 NETFQDDNGDQDNQSLSATLKTIRQQ 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	93/267 (35%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	93/266 (35%)
LOC100486333	XP_002936837.2	STKc_Nek	3..261	CDD:270855	95/274 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920