Protein Alignment Nek2 and LOC100486125

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_002933706.3
• Gene: LOC100486125 / 100486125
• XenbaseID: XB-GENE-29078175
• Length: 550
• Species: Xenopus tropicalis
• Alignment Length: 545
• Identity: 147/545 - (26%)
• Similarity: 229/545 - (42%)
• Gaps: 106/545 - (19%)

  Fly    19 YEVLAVMGNGSFGTCYKVRD-KSTGELFAWK-----GMNYD-ELDEAKCDALVSEISVLRQLQHP 76
            |.:...:|:|||.|.|.|.| |..|.....|     ||..| .|..|:      |..:|..|:||
 Frog    29 YNIHHTLGSGSFATAYLVTDAKDAGHQKVLKRIPCEGMKPDATLPSAR------EAKLLGSLRHP 87

  Fly    77 NIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNK 141
            .||::....:.:|  ...|:.|.|.||||...:|:.|.:.|.|.|.::.....||...:...|.:
 Frog    88 FIVRFLSSFLEKE--DFCIITEFCEGGDLQNRIQKQREKSQLFPEEHVMEWFIQLLLGVNYLHER 150

  Fly   142 IPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRK 206
            :    |||||:|..|||| ..|..|:||||::|:|......|.:|.|||||||||:::...|:.|
 Frog   151 L----ILHRDLKSKNIFL-KNGTVKIGDFGVSRILSMPSDMATTFTGTPHYMSPEVLEHYGYNAK 210

  Fly   207 SDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPG 271
            ||:|::||::||:||||..:....:.:|..:|.:|....:|:.||.:|.:|:..:|..|.:|||.
 Frog   211 SDIWSLGCILYEICALRHAYDSANWIKLVSQIVEGPCPSLPSQYSAELNDILKRVLNKDPQQRPS 275

  Fly   272 IEVIIRHPLVVRNISEL---------DGK--------FPILVDSGEDFYT------------LPS 307
            ...|:..|.||.:...|         :|:        ..|.|:..|..:.            .|.
 Frog   276 ASEILHMPTVVDHEKVLSIWLQEALHEGRQDCGSEDAARIAVEMQEKLHVDSLRIMRQVQEMAPR 340

  Fly   308 GARLFEDEEEDGVHPELSSTMFTEQY-SFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKK 371
            ..|....||:...|.:.........| ..:...||.|           |||:  :......||..
 Frog   341 QRRRIRKEEQQETHMKKIKRAVDRLYKEMHPKSGQNR-----------RSEI--NGDEDETPADV 392

  Fly   372 LQLSDPSLYESIRREERAEERQVE-------------LAEERRRKKDQEQQ-------------- 409
            :.:|:.|..:|....|.....::|             |:||:.......|.
 Frog   393 IHISEGSCKDSCSDSEEDISGEIEDKTLSSVLTISMPLSEEQSSTLSAYQSCLQHFLDSSTNGYG 457

  Fly   410 ----------KRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQELQ 464
                      ..::||........:.|.:..|.:|.:...|....|:|..::..|::....||::
 Frog   458 FGTSGASVSVCNEEELACLKQICLQCLGEEGFLKVYEYLKHIYSQQDSDYEESQEQVIFEPQEMR 522

  Fly   465 LAEQRVQTLERQMQEKLLQQE--KH 487
            |..|..|    |:|:.|..:|  ||
 Frog   523 LYPQHCQ----QVQQLLFLEERMKH 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	97/268 (36%)
LOC100486125	XP_002933706.3	Protein Kinases, catalytic domain	28..285	CDD:473864	97/268 (36%)