DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and LOC100328980

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001164656.1	Gene:	LOC100328980 / 100328980	-ID:	-	Length:	442	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	183/489 - (37%)
Similarity:	259/489 - (52%)	Gaps:	77/489 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            ::|||||..:|:||:|.|.|:|.:|.|:|..||.::|..:.||:...||||:::||:|:|||||:
Frog     5 VEDYEVLYTIGSGSYGKCQKIRRRSDGKLLVWKELDYGTMTEAEKQMLVSEVNLLRELKHPNIVR 69

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNG 145
            ||..:::|...::|||||.|.|||||.::.:...:||..||.:|.|:..||..||:.||.:...|
Frog    70 YYDRIIDRTNTTLYIVMEYCEGGDLASLIAKCTKERQYLEEDFILRIFSQLALALKDCHKRSDGG 134

  Fly   146 -TILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             |:||||:|||||||||..|.|||||||||:|..|.|||.:|||||:|||||.:....|:.|||:
Frog   135 HTVLHRDLKPANIFLDAKNNVKLGDFGLARILHHDSSFAKTFVGTPYYMSPEQMNRMSYNEKSDI 199

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            |::|||:||:|||.|||......:|:|||.:|.|.|||..||.:|.::|..||.:....||.||.
Frog   200 WSLGCLLYELCALSPPFTAYNQKELAEKIREGRFRRIPYRYSEELNQVITNMLHLKDYLRPSIEE 264

  Fly   275 IIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQYSFNEGY 339
            |::|.|:                           |.|..:|::.           ||:......
Frog   265 ILQHHLL---------------------------AELVREEQKK-----------TEKKVLRAA- 290

  Fly   340 GQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELAEERRRKK 404
            .|.|||:......:||           ...::|...:.:|.|   ||||.|:|:.||....|..:
Frog   291 EQERLSMPDPVPSELR-----------LKEQQLHTRERALRE---REERLEQRERELCVRERMAE 341

  Fly   405 DQ----EQQKRDQELLKEA----------------PSSPRALTQNIFDEVLKTRLHAIRAQESLL 449
            |:    |...:...|:||.                .||.|:.....|....|......|.:|
Frog   342 DKLARAETLVKSFNLMKEQHLFQAALENGKDAYVDSSSTRSRRHVHFGSNSKENSSTDRYRE--- 403

  Fly   450 QQKLEELQTREQELQLAEQRVQTLERQMQEKLLQ 483
            |:|..:||.|.|...:..:.:..|||..|.|..|
Frog   404 QEKCSDLQKRLQAANIRAKALSELERNYQLKSRQ 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	135/263 (51%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	134/262 (51%)
LOC100328980	NP_001164656.1	STKc_Nek2	7..271	CDD:270857	135/263 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1608
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I2729
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		oto105380
Panther	1	1.100	-	-	LDO	PTHR43671
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160