DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nek2 and herc5.3

DIOPT Version :9

Sequence 1:	NP_572415.1	Gene:	Nek2 / 31696	FlyBaseID:	FBgn0029970	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_021330683.1	Gene:	herc5.3 / 100073325	ZFINID:	ZDB-GENE-070615-14	Length:	1002	Species:	Danio rerio

Alignment Length:	582	Identity:	109/582 - (18%)
Similarity:	192/582 - (32%)	Gaps:	215/582 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NGSFGTCYKVRDKSTGELFAWKGMNYD-------ELDEAKCDALVSE-ISVLRQLQHPNIVQYYH 83
            ||||  ....||:.........|:::|       :|..:|  :|:|| :.|::|...|::   ..
Zfish   405 NGSF--LKTSRDEHYQTSVERCGLDFDLVKTSFAKLSTSK--SLISEVVKVVQQTLLPSL---NP 462

  Fly    84 HLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLC----RALQVCHNKIPN 144
            :....||..:|::        |.:::...:.||.:..|...:::| :||    :.|::..:::|
Zfish   463 NPTGEEALRLYLL--------LPELINGLKKQRTKLIEALAFKIL-ELCPAARKVLEMYWSRLP- 517

  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVK----GRKYDR 205
                                              |..|.| .:...|..|.||:|    |...|:
Zfish   518 ----------------------------------DDWFEA-LIKLFHKESAELIKQISRGETDDQ 547

  Fly   206 KS----DVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEII-------- 258
            .:    :...:..:.|::|.             |..|...:|. ||.:  .||.|.:
Zfish   548 STRHLKNFLEILQMAYQICC-------------STNITNHDFI-IPEV--NDLLETLDATSAEVL 596

  Fly   259 --AFMLAVDHEQRPGI----------EVIIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARL 311
              |..|.::.|....:          |::::.|.|                  .||.|..|...|
Zfish   597 WMASRLPINEELHNRMKLEDYYFKTAEILVKFPFV------------------SDFLTKKSMFIL 643

  Fly   312 FEDE--------------------EEDGVHPELSSTM-----FTEQYSFNEGYGQRRLSVTGVFT 351
            .:::                    ..:.|   |:.|:     ||  |||     ...|.|..:..
Zfish   644 LQEQCIRSLLDLLVVHLNGNLLHINRESV---LTDTLQYLRPFT--YSF-----MHPLQVAFIGE 698

  Fly   352 PDLRSEL----FYSAKRKIF---PAKKLQLSDPSLYESIRREERAEERQVELAEERRRKKDQEQQ 409
            .::..::    |:|...|.|   ..|.|::.:.||...                    .....|.
Zfish   699 DEIDEKVISAEFFSLISKSFIEWDKKILEVHESSLVWF--------------------NPHHTQD 743

  Fly   410 KRDQELLKEAPSSPRALTQNIFDEVLKTRLH-----AIRAQESLLQQK--LEELQTREQELQLAE 467
            .||...|..           |....|..|.|     .:...:.|||||  |::|    :||...|
Zfish   744 HRDFYYLGV-----------ICGMALYNRHHINIDFPLALFKKLLQQKPSLDDL----EELSPVE 793

  Fly   468 QR-VQTLERQMQEKL--LQQEKHTCSCRQ--PIAPPIPPRKPAKSHHDDTYCTIELNETSPT 524
            .| ::.|..:.:|::  ||....||..::  |....|...|..:..:.|.|.....|::..|
Zfish   794 ARSLKNLLEEDEEEVVDLQHLDFTCKGQELVPNGSQIQVNKVNRQKYVDLYVDFVFNKSVKT 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	53/293 (18%)
Nek2	NP_572415.1	S_TKc	19..281	CDD:214567	53/293 (18%)
herc5.3	XP_021330683.1	RCC1	<74..349	CDD:332518
herc5.3	XP_021330683.1	HECTc	665..1000	CDD:331829	50/236 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010