Protein Alignment Nek2 and nek1

DIOPT Version :10

• Sequence 1: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_012827049.2
• Gene: nek1 / 100036653
• XenbaseID: XB-GENE-983162
• Length: 1320
• Species: Xenopus tropicalis
• Alignment Length: 747
• Identity: 185/747 - (24%)
• Similarity: 311/747 - (41%)
• Gaps: 162/747 - (21%)

  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80
            :..|..::.:|.||||....|:.|..|:.:..|.:...::...:.:....|::||..::||||||
 Frog     1 MNKYVRVSKIGEGSFGKAILVKSKDDGKQYVIKEIGISKMSNKEREESRREVAVLANMKHPNIVQ 65

  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR-QRFEEPYIWRVLFQLCRALQVCHNKIPN 144
            |....  .|:..:||||:.|.||||   .:|..||: ..|.|..|.....|||.||:..|::
 Frog    66 YQESF--EESGCLYIVMDYCEGGDL---FKRINSQKGVLFSEDQILDWFVQLCLALKHVHDR--- 122

  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209
             .|||||||..||||...|..:|||||:||:|......|.:.:|||:|:|||:.:.|.|:.|||:
 Frog   123 -KILHRDIKSQNIFLTKGGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENRPYNNKSDI 186

  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274
            ||:||::||||.|:..|.......|..||.:|.:..:...||.||:.:::.:...:...||.:..
 Frog   187 WALGCVLYEMCTLKHAFEAGNMKNLVLKIIRGSYPPVSVHYSYDLRNLLSMLFKRNPRDRPSVNS 251

  Fly   275 IIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQYSFNEGY 339
            |:..|.:.|.|.    ||                               ||.....|::..
 Frog   252 ILEKPFIYRRIE----KF-------------------------------LSPQHIAEEFGL---- 277

  Fly   340 GQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERAEERQVELAEER---- 400
                    |.|....:..:..:|.::..||:.:..|.|:  ..|.:.  |.:..|.|..::
 Frog   278 --------GAFVNHPKPGIQAAAAKRPTPAQVVPASPPA--HKITKP--AAKYGVPLTTKKSSDA 330

  Fly   401 -RRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQKLEELQTREQELQ 464
             ::..|::.|.|.    ::||:.|.... |..||..|......:.:...::|..:|.:.|||...
 Frog   331 AKKHHDKKPQIRH----RQAPAVPLKKV-NPVDERRKMFEDGAKKKRMDVRQLEKEKRQREQFNL 390

  Fly   465 LAEQRVQTLERQMQEKLLQQEKH----------TCSCRQP-------IAPPIPPRKPAKSHHDDT 512
            |..::::.||::..|::.:..:.          :...:.|       :|||....:....|:...
 Frog   391 LRAEQMRRLEKERLERINRAREQGWRNVISSGGSGDIKAPYFGGGGGVAPPQGMGRGPYEHYHSI 455

  Fly   513 YCTIELNETSPTVAKLNLATLPAP-KSLNTLRKVTFKSPQKFVTYGIENMPPPAVKPAVNPPPTG 576
            :..::..:.:...|......|.|. ::.:|..:|. |.|::      ||.|     .|.:|.|.|
 Frog   456 FDQMQQQKENIKAAVEKEVKLKADIQNPDTYSRVP-KHPEQ------ENCP-----SAHSPFPDG 508

  Fly   577 VPMQMSVSSNDSGDSQASSTRRKSILSLFGLSRGSKATSKSLPSVNQVAQAAATRVQRPPLAVKP 641
                             .:.||:               .|.|..|:.  ||...::|....|.|.
 Frog   509 -----------------DAVRRE---------------LKRLQEVHN--QAIGNKIQGHVSAEKA 539

  Fly   642 PITQEQPAEVPPVANLWTKEQKKQAFELLAA----MNAAEREAS--GGGVVGSGPGGARRQ---- 696
            ...:|            ..::|.:|.:..|.    |:|....|:  ||....:|.|.||.:
 Frog   540 RQVEE------------FLQRKHEAMQNKARAEGHMDAVHNLAAICGGRPNSAGGGKARNREEKE 592

  Fly   697 ---HLRQSVRERNSTLQRNRMRRSLVVATGHQ 725
               .||| :|.:|.. :|.:::..|..|.|.:
 Frog   593 YLARLRQ-IRLQNFN-ERQQIKAKLRGAKGDE 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	97/263 (37%)
nek1	XP_012827049.2	STKc_Nek1	3..258	CDD:270858	97/263 (37%)