DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10932 and acat1

DIOPT Version :9

Sequence 1:	NP_001284987.1	Gene:	CG10932 / 31695	FlyBaseID:	FBgn0029969	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_001003746.1	Gene:	acat1 / 445290	ZFINID:	ZDB-GENE-040808-68	Length:	420	Species:	Danio rerio

Alignment Length:	419	Identity:	261/419 - (62%)
Similarity:	329/419 - (78%)	Gaps:	10/419 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSARLLQATR----RWSAH----RNYSSK--IAEVVVVSAARTPIGSFQSQLAPLTATQLGARAI 55
            |::|.|.:||    |..||    |:||::  :.|||:|||.|||||||:..|:.|.||:||:.||
Zfish     1 MTSRALYSTRSQLCRHLAHKYLSRSYSTRPSLNEVVIVSAVRTPIGSFKGSLSTLPATKLGSIAI 65

  Fly    56 EAAIEKAGIAKTDVQEVIMGNVVSAGLGQAPARQAAIFAGLPTNVCCTTVNKVCSSGMKAVMLGA 120
            :.||:||||...:|:||.||||:.||.||||.|||.:.||||.:...||:||||:||||::||.:
Zfish    66 KGAIDKAGIPVEEVKEVYMGNVLQAGEGQAPTRQALLGAGLPLSTPATTINKVCASGMKSIMLAS 130

  Fly   121 QSLMLGYADVVVAGGMESMSNVPYYLKRGATPYGGVNLTDGIVFDGLWDVYNKFHMGNCAENTAK 185
            ||||.|:.||:|||||||||.|||.:.|.|.|||||.:.|.||.|||.|||||||||||||||||
Zfish   131 QSLMCGHQDVMVAGGMESMSQVPYIMAREAPPYGGVKMEDLIVKDGLTDVYNKFHMGNCAENTAK 195

  Fly   186 KLEITRQQQDDFAIESYKRSAAAWANKVFQDEIAPVKIQQKRKPEIVISEDEEYKRVNFDKFGQL 250
            ...|:|::||.|||:||..|.|||.:.:...|:.||.|.|:.||::|:.|||||::|:|.|..:|
Zfish   196 NSSISREEQDAFAIKSYTLSKAAWESGILAKEVVPVSIPQRGKPDVVVKEDEEYRKVDFSKVPKL 260

  Fly   251 ATVFQRENGTVTAGNASTLNDGGAAVVLMSAEAAQKAGIKPLARIVAFQDAETDPIDFPIAPALA 315
            ..||.:|||||||.||||||||.||:|||:|:|||:..:.|||:||||.||...|||||||||.|
Zfish   261 KAVFLKENGTVTAANASTLNDGAAALVLMTADAAQRLNVTPLAKIVAFADAAVAPIDFPIAPAFA 325

  Fly   316 IPKLLKRAGVRKEDVAMWEVNEAFSLVVLANIKKLDVDPAKVNVHGGAVSIGHPIGMSGARLVAH 380
            :||:||.||::|||:||||:|||||:|||||||.||:||.:||::|||||:||||||||||:|.|
Zfish   326 VPKVLKAAGIKKEDIAMWEINEAFSVVVLANIKMLDIDPDRVNINGGAVSLGHPIGMSGARIVGH 390

  Fly   381 LSHSLKKGELGCASICNGGGGASSILIEK 409
            :.|:||.|:.|.|.|||||||||||:|:|
Zfish   391 MVHNLKSGQYGLAGICNGGGGASSIVIQK 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10932	NP_001284987.1	PLN02644	24..410	CDD:215347	250/386 (65%)
CG10932	NP_001284987.1	thiolase	26..409	CDD:238383	247/382 (65%)
acat1	NP_001003746.1	PLN02644	34..418	CDD:215347	248/383 (65%)
		thiolase	36..419	CDD:238383	247/382 (65%)
		Coenzyme A binding. /evidence=ECO:0000250\|UniProtKB:P24752	251..253		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580339
Domainoid	1	1.000	318	1.000	Domainoid score	I1227
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1251
OMA	1	1.010	-	-		QHG60894
OrthoDB	1	1.010	-	-		D321628at33208
OrthoFinder	1	1.000	-	-		FOG0000432
OrthoInspector	1	1.000	-	-		oto39771
orthoMCL	1	0.900	-	-		OOG6_100472
Panther	1	1.100	-	-	LDO	PTHR18919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1511
SonicParanoid	1	1.000	-	-		X2197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940