DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10932 and kat-1

DIOPT Version :9

Sequence 1:	NP_001284987.1	Gene:	CG10932 / 31695	FlyBaseID:	FBgn0029969	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_495455.2	Gene:	kat-1 / 174161	WormBaseID:	WBGene00002183	Length:	407	Species:	Caenorhabditis elegans

Alignment Length:	384	Identity:	225/384 - (58%)
Similarity:	291/384 - (75%)	Gaps:	2/384 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VVSAARTPIGSFQSQLAPLTATQLGARAIEAAIEKAGIAKTDVQEVIMGNVVSAGLGQAPARQAA 91
            :|.|||||||||:|.|:.:||.:|.:.||:||:|:..:..:.:|||.:|.|..|..|||||||||
Worm    26 IVGAARTPIGSFRSSLSSVTAPELASVAIKAALERGAVKPSSIQEVFLGQVCQANAGQAPARQAA 90

  Fly    92 IFAGLPTNVCCTTVNKVCSSGMKAVMLGAQSLMLGYADVVVAGGMESMSNVPYYLKRGATPYGGV 156
            :.|||..:|..||||||||||:||::|.||.:..|:.|..:.|||||||.||:|::||..||||.
Worm    91 LGAGLDLSVAVTTVNKVCSSGLKAIILAAQQIQTGHQDFAIGGGMESMSQVPFYVQRGEIPYGGF 155

  Fly   157 NLTDGIVFDGLWDVYNKFHMGNCAENTAKKLEITRQQQDDFAIESYKRSAAAWANKVFQDEIAPV 221
            .:.||||.|||.|.|:|.|||||.|.|:|::.|||:.||::||.|||:||.||.|.....|:.||
Worm   156 QVIDGIVKDGLTDAYDKVHMGNCGEKTSKEMGITRKDQDEYAINSYKKSAKAWENGNIGPEVVPV 220

  Fly   222 KIQQKRKPEIVISEDEEYKRVNFDKFGQLATVFQRENGTVTAGNASTLNDGGAAVVLMSAEAAQK 286
            .::.| |...::.:|||:.:||||||..|.||||:: ||:||.||||||||.|||::.|.||..:
Worm   221 NVKSK-KGVTIVDKDEEFTKVNFDKFTSLRTVFQKD-GTITAANASTLNDGAAAVIVASQEAVSE 283

  Fly   287 AGIKPLARIVAFQDAETDPIDFPIAPALAIPKLLKRAGVRKEDVAMWEVNEAFSLVVLANIKKLD 351
            ..:||||||:|:.||.|.|:||.:||.|..||:|:||||::.|||.||||||||.|.||.||||.
Worm   284 QSLKPLARILAYGDAATHPLDFAVAPTLMFPKILERAGVKQSDVAQWEVNEAFSCVPLAFIKKLG 348

  Fly   352 VDPAKVNVHGGAVSIGHPIGMSGARLVAHLSHSLKKGELGCASICNGGGGASSILIEKL 410
            |||:.||.||||||||||||||||||:.||.|:||.|::|.|:|||||||:|.::|:||
Worm   349 VDPSLVNPHGGAVSIGHPIGMSGARLITHLVHTLKSGQIGVAAICNGGGGSSGMVIQKL 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10932	NP_001284987.1	PLN02644	24..410	CDD:215347	223/382 (58%)
CG10932	NP_001284987.1	thiolase	26..409	CDD:238383	223/381 (59%)
kat-1	NP_495455.2	thiolase	25..406	CDD:238383	223/381 (59%)
kat-1	NP_495455.2	PLN02644	26..407	CDD:215347	223/382 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159103
Domainoid	1	1.000	285	1.000	Domainoid score	I854
eggNOG	1	0.900	-	-		E1_COG0183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6
Inparanoid	1	1.050	460	1.000	Inparanoid score	I876
Isobase	1	0.950	-	0	Normalized mean entropy	S424
OMA	1	1.010	-	-		QHG60894
OrthoDB	1	1.010	-	-		D1011220at2759
OrthoFinder	1	1.000	-	-		FOG0000432
OrthoInspector	1	1.000	-	-		oto17912
orthoMCL	1	0.900	-	-		OOG6_100472
Panther	1	1.100	-	-	LDO	PTHR18919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1511
SonicParanoid	1	1.000	-	-		X2197
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790