DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10932 and Acat1

DIOPT Version :9

Sequence 1:	NP_001284987.1	Gene:	CG10932 / 31695	FlyBaseID:	FBgn0029969	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_659033.1	Gene:	Acat1 / 110446	MGIID:	87870	Length:	424	Species:	Mus musculus

Alignment Length:	408	Identity:	275/408 - (67%)
Similarity:	327/408 - (80%)	Gaps:	4/408 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLQATRRWSAHRNYSSK--IAEVVVVSAARTPIGSFQSQLAPLTATQLGARAIEAAIEKAGIAKT 67
            |||..|  ...|:|:||  :.|||:|||.|||||||...||...||:||..||:.|||||||.|.
Mouse    19 LLQEVR--CLERSYASKPTLNEVVIVSAIRTPIGSFLGSLASQPATKLGTAAIQGAIEKAGIPKE 81

  Fly    68 DVQEVIMGNVVSAGLGQAPARQAAIFAGLPTNVCCTTVNKVCSSGMKAVMLGAQSLMLGYADVVV 132
            :|:||.||||:..|.||||.|||.:.||||.:..||||||||:|||||:|:.:||||.|:.||:|
Mouse    82 EVKEVYMGNVIQGGEGQAPTRQATLGAGLPISTPCTTVNKVCASGMKAIMMASQSLMCGHQDVMV 146

  Fly   133 AGGMESMSNVPYYLKRGATPYGGVNLTDGIVFDGLWDVYNKFHMGNCAENTAKKLEITRQQQDDF 197
            ||||||||||||.:.|||||||||.|.|.||.|||.|||||.||||||||||||:.|:||:||.:
Mouse   147 AGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKMNISRQEQDTY 211

  Fly   198 AIESYKRSAAAWANKVFQDEIAPVKIQQKRKPEIVISEDEEYKRVNFDKFGQLATVFQRENGTVT 262
            |:.||.||..||....|..||.|:.|..|.||::|:.||||||||:|.|..:|.||||:||||:|
Mouse   212 ALSSYTRSKEAWDAGKFASEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTIT 276

  Fly   263 AGNASTLNDGGAAVVLMSAEAAQKAGIKPLARIVAFQDAETDPIDFPIAPALAIPKLLKRAGVRK 327
            |.||||||||.||:|||:|||||:..:||||||.||.||..||||||:|||.|:||:||.||::|
Mouse   277 AANASTLNDGAAALVLMTAEAAQRLNVKPLARIAAFADAAVDPIDFPLAPAYAVPKVLKYAGLKK 341

  Fly   328 EDVAMWEVNEAFSLVVLANIKKLDVDPAKVNVHGGAVSIGHPIGMSGARLVAHLSHSLKKGELGC 392
            ||:||||||||||:|||||||.|::||.|||:||||||:||||||||||:|.|::|:||.||.|.
Mouse   342 EDIAMWEVNEAFSVVVLANIKMLEIDPQKVNIHGGAVSLGHPIGMSGARIVVHMAHALKPGEFGL 406

  Fly   393 ASICNGGGGASSILIEKL 410
            |||||||||||::|||||
Mouse   407 ASICNGGGGASALLIEKL 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10932	NP_001284987.1	PLN02644	24..410	CDD:215347	265/385 (69%)
CG10932	NP_001284987.1	thiolase	26..409	CDD:238383	262/382 (69%)
Acat1	NP_659033.1	PLN02644	38..424	CDD:215347	265/385 (69%)
		thiolase	40..423	CDD:238383	262/382 (69%)
		Coenzyme A binding. /evidence=ECO:0000250\|UniProtKB:P24752	255..257		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836831
Domainoid	1	1.000	339	1.000	Domainoid score	I1098
eggNOG	1	0.900	-	-		E1_COG0183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1138
Isobase	1	0.950	-	0	Normalized mean entropy	S424
OMA	1	1.010	-	-		QHG60894
OrthoDB	1	1.010	-	-		D321628at33208
OrthoFinder	1	1.000	-	-		FOG0000432
OrthoInspector	1	1.000	-	-		oto94430
orthoMCL	1	0.900	-	-		OOG6_100472
Panther	1	1.100	-	-	LDO	PTHR18919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1511
SonicParanoid	1	1.000	-	-		X2197
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750