DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7g and grik1a

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	699	Identity:	131/699 - (18%)
Similarity:	236/699 - (33%)	Gaps:	212/699 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LNFESMKYIGAQTQAASI----NHHVAQALRVFIEDFYQRIAPAFIVVLSCRRPSP-MNFYRNIM 66
            |:.|..:|.|....|..:    :.:||..::.:  ...:::||          |.| ......||
Zfish   267 LDLEPYRYSGVNMTAFRLLNLDDSYVASVIQKW--SMERQLAP----------PKPESGLMSGIM 319

  Fly    67 ----QLLYESVDTMIV------QLVLVEL----GRPRRIAGPRTHNLLLVDSLDALLDIEIHTYT 117
                .|:|::|..:.|      |:.:..|    .:|.|. |||..||......|.|        |
Zfish   320 TTAAALMYDAVFMVAVASQRATQMTVSSLQCHRHKPWRY-GPRFMNLFKEAQWDGL--------T 375

  Fly   118 AQSDTSEYYFIFLQQRDALIPHDMQGVFAYCWRHQLINCNVMTQSSGGQVLLHTYFPYAPGQCND 182
            .:        |.|.:.|.|              .:..|.::::....|     |....|.|.
Zfish   376 GR--------IVLNKTDGL--------------RKEFNLDLISLKEDG-----TAKRVADGA--- 410

  Fly   183 SQPTRI-------NMFLG---ESWKHRDYFPSKLHNLNGCPLIVLARKVSPFLDLDEGQRELRG- 236
            |:|.::       |.:.|   ...|........|.|..   |||.....:|::...:..:.|.|
Zfish   411 SRPNKLWTKIGVWNSYTGLNLTEIKDNKNITDSLANRT---LIVTTILENPYVMYKKSDKVLYGN 472

  Fly   237 --LEG---RLLQELSRRMNFSIQFS-------GLQDQLKNRTTWTEKQLLQKLVQERIAHLAIGY 289
              .||   .||:|||..:.|:.:..       |.|:. |.......::|:..:....:|.|.|.|
Zfish   473 DRFEGYCLDLLKELSNILGFTYEVKLVTDGKYGAQND-KGEWNGMVRELIDHIADLAVAPLTITY 536

  Fly   290 VRKRIQYATNLTPVFPHYSNRVVG-CLLLNAHNLTSLEIWSF--PFQALTWICLVFSFLSISCLA 351
            ||:::   .:.:..|     ..:| .:|....|.|:..::||  |.....|:.::.:.|.:||:.
Zfish   537 VREKV---IDFSKPF-----MTLGISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCVL 593

  Fly   352 LLHXRGAGDRLALVLAVYAASLGLPIDP------------------------------PERPSLQ 386
            .:..|         ...|......|.:|                              |:..|.:
Zfish   594 FVIAR---------FTPYEWYNPHPCNPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKALSTR 649

  Fly   387 LLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDL---THGDYAAVMGRTTLQDLR--EV 446
            :|...|..|.||:.|.|:|.|...|..........:..||   |..:|.||...:|:...:  ::
Zfish   650 ILGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTRIEYGAVRDGSTMTFFKKSKI 714

  Fly   447 PSLQDLLGL----KSVIVTSEREEEVLR--TLDRCTLREGAGSHPLFFGLISQDALLHLTQR--- 502
            .:.:.:...    |:..:....::.:.|  |.|...|.|..             ::.::|||
Zfish   715 STYEKMWAFMSSRKNTALVKNSKDGITRVLTTDYALLMEST-------------SIEYITQRNCN 766

  Fly   503 -----------GHRAGAYHIIPQDVLEQQLAIYLQKHSHLASHLDHLVMSIRSVGLVHHWAGQMA 556
                       |:..|.....|          |..|       :...::.::..|.:|     |.
Zfish   767 LTQVGGLIDSKGYGVGTPIGSP----------YRDK-------VTIAILQLQEEGKLH-----MM 809

  Fly   557 SERYFRSRFLYRE-----KRIRQPDLWAVYILTAGLYLLSLVVFICELL 600
            .|:::|......|     ..:...::..::|:.|...:||:.|.|.|.:
Zfish   810 KEKWWRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFI 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	42/215 (20%)
		ANF_receptor	57..398	CDD:279440	34/173 (20%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	78/424 (18%)
		Lig_chan	577..846	CDD:278489	49/312 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930