DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7g and Grid2

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	103/474 - (21%)
Similarity:	168/474 - (35%)	Gaps:	123/474 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 HNLNGCPLIVLARKVSPFLDLDEG----QRELRGLEGRLLQELSRRMNFSIQFSGLQDQL----K 263
            :|:.|..|.|:.....||:.:.|.    .::.:|....:|..||..:.|:.:.....|..    :
  Rat   436 NNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQ 500

  Fly   264 NRTTWTEKQLLQKLVQER----IAHLAIGYVRKRIQYATNLTPVFPHYSNRVVGCLLLNAHNLTS 324
            ...||  ..|:.:||.:|    |:.|.|...|:.:   .:.|..:..||   ||.||..|.....
  Rat   501 EDGTW--NGLVGELVFKRADIGISALTITPDRENV---VDFTTRYMDYS---VGVLLRRAEKTVD 557

  Fly   325 LEIWSFPFQALTWICLVFSFLSISCLALLHXRGAGDRLALVLAVYAASLGLPIDPP--------- 380
            :.....||....|.|:                 ||..|.:.|.||..:.   ::||
  Rat   558 MFACLAPFDLSLWACI-----------------AGTVLLVGLLVYLLNW---LNPPRLQMGSMTS 602

  Fly   381 -------------------ERP----SLQLLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGN 422
                               |.|    :.:::..:|.:|.|||.|.|:|.|...|.....:....:
  Rat   603 TTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQS 667

  Fly   423 LQDL---THGDYAAVMGRTTLQDLREVPSLQDLLGLKSVIVTSERE---EEVLRTLDRC------ 475
            ||||   |...|..|:.....|.:|       :.||...    ||:   .::.|.::|.
  Rat   668 LQDLSKQTDIPYGTVLDSAVYQHVR-------MKGLNPF----ERDSMYSQMWRMINRSNGSENN 721

  Fly   476 TLREGAGSHPLFFG---LISQDALLHLTQRGHRAGAYHIIPQDVLEQQLAIYLQKHSHLASHLDH 537
            .|...||...:.:|   .:...|:|..........:::.:...|.::...|.||..|........
  Rat   722 VLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQ 786

  Fly   538 LVMSIRSVG----LVHHW---AGQMASERYFRSRFLYREKRIRQ-------PDLWAVY-ILTAGL 587
            .::.::..|    |.|.|   .||..         ||.....:|       ..|..|: ||.||:
  Rat   787 RILELQQSGDMDILKHKWWPKNGQCD---------LYSSVDAKQKGGALDIKSLAGVFCILAAGI 842

  Fly   588 YLLSLVVFICELLASRRAG 606
             :||.::.:.|...|||.|
  Rat   843 -VLSCLIAVLETWWSRRKG 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822
		PBP2_iGluR_delta_2	440..806	CDD:270449	84/404 (21%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349995
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840