DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7g and GRIN2B

DIOPT Version :10

Sequence 1:NP_001368933.1 Gene:Ir7g / 31694 FlyBaseID:FBgn0029968 Length:607 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:448 Identity:84/448 - (18%)
Similarity:160/448 - (35%) Gaps:158/448 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   241 LLQELSRRMNFSIQF----SGLQDQLKNRTTWTEKQLLQKLVQERIAHLAIGYV---RKRIQYAT 298
            :|:::|:.:.|:...    :|...: |...||  ..::.::|.:| |::|:|.:   .:|.:...
Human   464 ILKKISKSVKFTYDLYLVTNGKHGK-KINGTW--NGMIGEVVMKR-AYMAVGSLTINEERSEVVD 524

  Fly   299 NLTPVFPHYSNRVVGCLLLNAHNLTSLEIWSFPFQALTWICLVFSFLSIS--------------- 348
            ...|    :....:..::..::...|...:..||.|..|:.:....|.:|               
Human   525 FSVP----FIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY 585

  Fly   349 --CLALLHXRGAGDRLALVLAVY-----AASLGLPIDPPERPSLQLLFASWLIFGLIVRSMYSAL 406
              |||... .| |....:..|::     ..:..:|:..|:..:.:::.:.|..|.:|..:.|:|.
Human   586 NRCLADGREPG-GPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 649

  Fly   407 L--FFILRYHLHQ----------------------RLP-GNLQDLTHGDYA---AVMGRTTLQDL 443
            |  |.|...::.|                      .:| |:.:.....:||   |.||:...:.:
Human   650 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGV 714

  Fly   444 REVPSLQDLLGLKSVIVTSEREEEVLRTLDRCTLR------EGA-----GSHPLF----FGL-IS 492
            .:.     ||.||    |.:.:..:   .|...|.      ||.     ||..:|    :|: |.
Human   715 DDA-----LLSLK----TGKLDAFI---YDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQ 767

  Fly   493 QD---------ALLHLTQRGHRAGAYHIIPQDVLEQQLAIYL------QKHSHLASHLDHLVMSI 542
            :|         |:|.|...|.            :|:..|::|      :|:..::|.||      
Human   768 KDSGWKRQVDLAILQLFGDGE------------MEELEALWLTGICHNEKNEVMSSQLD------ 814

  Fly   543 RSVGLVHHWAGQMASERYFRSRFLYREKRIRQPDLWAVYILTAGLYLLSLVVFICELL 600
                 :.:.||                         ..|:|.|.: .|||:.||||.|
Human   815 -----IDNMAG-------------------------VFYMLGAAM-ALSLITFICEHL 841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir7gNP_001368933.1 None
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 67/371 (18%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 2/18 (11%)
NMDAR2_C 840..1484 CDD:463148 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1074..1097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1194
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1301
Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097 1292..1304
PDZ-binding. /evidence=ECO:0000250 1482..1484
Blue background indicates that the domain is not in the aligned region.

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