Protein Alignment Ir7g and GRIK3

DIOPT Version :10

• Sequence 1: NP_001368933.1
• Gene: Ir7g / 31694
• FlyBaseID: FBgn0029968
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_000822.2
• Gene: GRIK3 / 2899
• HGNCID: 4581
• Length: 919
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 118/564 - (20%)
• Similarity: 205/564 - (36%)
• Gaps: 126/564 - (22%)

  Fly    17 AQTQAASINHHVAQALRV-FIEDFYQRIAPAFIVVLSCRRPSPMNFYR----NIMQLLYESVDTM 76
            :.|.||.|   :.||:.: .:.::|..|.....:......|     ||    |:......:||..
Human   234 SHTMAAQI---LKQAMAMGMMTEYYHFIFTTLDLYALDLEP-----YRYSGVNLTGFRILNVDNP 290

  Fly    77 IVQLVLVELGRPRRIAGPRTHNLLL--VDSLDALLDIEIHTYTAQSDTSEYYFIFLQQRDALIPH 139
            .|..::.:....|..|.||:.:.||  |...||.|     .|.|....|..|    |:...:..:
Human   291 HVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAAL-----LYDAVHIVSVCY----QRAPQMTVN 346

  Fly   140 DMQGVFAYCWRHQ-------------------LINCNVMTQSSGGQVLLHTYFPYAPGQCNDSQP 185
            .:|     |.||:                   |....|..::||    |.|.|........:...
Human   347 SLQ-----CHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSG----LRTDFDLDIISLKEDGL 402

  Fly   186 TRINMF-------LGESWKHRDYFPSKLHNLNGCPLIVLARKVSPFLDLDEGQRELRG---LEG- 239
            .::.::       :.|..|.|.  |:...:|....|||......||:...:..|.|.|   .||
Human   403 EKVGVWSPADGLNITEVAKGRG--PNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGY 465

  Fly   240 --RLLQELSRRMNFSIQFS-------GLQDQLKNRTTWTEKQLLQKLVQERIAHLAIGYVRKRIQ 295
              .||:||:..:.||.:..       |.||. |.:.....|:|:.......:|.|.|.:||::
Human   466 CIDLLKELAHILGFSYEIRLVEDGKYGAQDD-KGQWNGMVKELIDHKADLAVAPLTITHVREK-- 527

  Fly   296 YATNLTPVFPHYSNRVVG-CLLLNAHNLTSLEIWSF--PFQALTWICLVFSFLSISCLALL---- 353
             |.:.:..|     ..:| .:|....|.|:..::||  |.....|:.::.::|.:||:..:
Human   528 -AIDFSKPF-----MTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARF 586

  Fly   354 --------HXRGAGDRLA----LVLAVYAASLGLPIDP-----PERPSLQLLFASWLIFGLIVRS 401
                    |....|..:.    .:|..:...:|..:..     |:..|.:::...|..|.||:.|
Human   587 SPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIIS 651

  Fly   402 MYSALLFFILRYHLHQRLPGNLQDL---THGDYAAVMGRTTLQDLR--EVPSLQDL---LGLKSV 458
            .|:|.|...|.....:....:..||   |..:|.||....|:...:  ::.:.:.:   :..|..
Human   652 SYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPS 716

  Fly   459 IVTSEREEEVLRTLDRCTLREGAGSHPLFFGLISQDALLHLTQR 502
            .:....||.:.|.|        ...:.|   |:....:.::|||
Human   717 ALVKNNEEGIQRAL--------TADYAL---LMESTTIEYVTQR 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
GRIK3	NP_000822.2	PBP1_iGluR_Kainate	37..417	CDD:380605	41/208 (20%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	72/337 (21%)