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Protein Alignment Ir7g and GRIK1

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	703	Identity:	131/703 - (18%)
Similarity:	235/703 - (33%)	Gaps:	210/703 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LNFESMKYIGAQTQAASI----NHHVAQALRVFIEDFYQRIAPAFIVVLSCRRPSPMNFYRNIMQ 67
            |:.|..:|.|.......:    |.||:..:..:..:..|  ||          |.|.....:.|.
Human   265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQ--AP----------PRPETGLLDGMM 317

  Fly    68 -----LLYESVDTMIV------QLVLVEL----GRPRRIAGPRTHNLLLVDSLDAL--------- 108
                 |:|::|..:.:      ||.:..|    .:|.|: |||..||:.....|.|
Human   318 TTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRL-GPRFMNLIKEARWDGLTGHITFNKT 381

  Fly   109 ------LDIEIHTYTAQSDTSEYYFIFLQQRDALIPHDMQGVFAYCWRHQLINCNVMTQSSGGQV 167
                  .|::|              |.|::..                         |:.:.|:|
Human   382 NGLRKDFDLDI--------------ISLKEEG-------------------------TEKAAGEV 407

  Fly   168 LLHTYFPYAP-GQCNDSQPTRINMFLGESWKHRDYFPSKLHNLNGCPLIVLARKVSPFLDLDEGQ 231
            ..|.|..:.. |..|.      |..|..:..::|...:...:|....|||......|::...:..
Human   408 SKHLYKVWKKIGIWNS------NSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSD 466

  Fly   232 RELRG---LEG---RLLQELSRRMNFSIQFS-------GLQDQLKNRTTWTEKQLLQKLVQERIA 283
            :.|.|   .||   .||:|||..:.|.....       |.|:. |.......|:|:.......:|
Human   467 KPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND-KGEWNGMVKELIDHRADLAVA 530

  Fly   284 HLAIGYVRKRIQYATNLTPVFPHYSNRVVG-CLLLNAHNLTSLEIWSF--PFQALTWICLVFSFL 345
            .|.|.|||:::   .:.:..|     ..:| .:|....|.|:..::||  |.....|:.::.:.|
Human   531 PLTITYVREKV---IDFSKPF-----MTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACL 587

  Fly   346 SISCLALLHXRGAGDRLALVLAVYAASLGLPIDP------------------------------P 380
            .:||:..:..|         ...|......|.:|                              |
Human   588 GVSCVLFVIAR---------FTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMP 643

  Fly   381 ERPSLQLLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDL---THGDYAAVMGRTTLQD 442
            :..|.:::...|..|.||:.|.|:|.|...|.....:....:..||   |..:|.||...:|:..
Human   644 KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTF 708

  Fly   443 LR--EVPSLQDLLGLKSVIVTSEREEEVLRTLDRCTLREGAGSHPLFFGLISQDALLHLTQR--- 502
            .:  ::.:.:.:....|    |.::..::|..|....|.....:.|   |:...::.::|||
Human   709 FKKSKISTYEKMWAFMS----SRQQTALVRNSDEGIQRVLTTDYAL---LMESTSIEYVTQRNCN 766

  Fly   503 -----------GHRAGAYHIIPQDVLEQQLAIYLQKHSHLASHLDHLVMSIRSVGLVHHWAGQMA 556
                       |:..|.....|          |..|       :...::.::..|.:|     |.
Human   767 LTQIGGLIDSKGYGVGTPIGSP----------YRDK-------ITIAILQLQEEGKLH-----MM 809

  Fly   557 SERYFRSRFLYRE-----KRIRQPDLWAVYILTAGLYLLSLVVFICELLASRR 604
            .|:::|......|     ..:...::..::|:.|...:||:.|.|.|.:...|
Human   810 KEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 862

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.