Protein Alignment Ir7g and GRID1

DIOPT Version :10

• Sequence 1: NP_001368933.1
• Gene: Ir7g / 31694
• FlyBaseID: FBgn0029968
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 145/773 - (18%)
• Similarity: 248/773 - (32%)
• Gaps: 263/773 - (34%)

  Fly     3 VTSLLNFESMKYIGAQTQAASINHHVAQALRVFIEDFYQR----IAPAFIVVLSCRRPSPMNFYR 63
            ||.|...:.:.:..::.....:...:.||.|:.::...|:    |:..|..:.:..:...:|.||
Human   157 VTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYR 221

  Fly    64 NIMQ-------------LLYESVDT-------------------MIVQLVLVELGR---PRRI-- 91
            :.::             .:.|:|:|                   .|:.||...|||   .|:|
Human   222 DTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFP 286

  Fly    92 -------AGPRTHNL--LLVDSLDALLDI----EIHTYTAQSDTSEYYFIFLQQRDALIPHDMQG 143
                   .....|.:  ||.|..:..|.:    .::.|.:....:..:...|:.|.
Human   287 SAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRK--------- 342

  Fly   144 VFAYCWRHQLINCNVMTQS----SGGQVLLHT----YFPYAPG----QCNDSQP--------TRI 188
                 | |.:.:.|.:.:|    :||:.:|.|    :.....|    :.:.|.|        |..
Human   343 -----W-HSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTY 401

  Fly   189 NMFLGE------SWKHRDYFPSKLH------NLNGCPLIVLARKVSPFLDLDE---GQ-RELRGL 237
            :...|:      :|.........|.      .|.|..|.|:.....||:.:.|   || :..:|.
Human   402 SETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGF 466

  Fly   238 EGRLLQELSRRMNFSIQFSGLQD-----QLKNRTTWTEKQLLQKLVQERIAHLAIGYVRKRIQYA 297
            ...:|..|::.:.|..:.....|     ||.| |:|  ..::.:|:.:| |.|||.        |
Human   467 SIDVLDALAKALGFKYEIYQAPDGRYGHQLHN-TSW--NGMIGELISKR-ADLAIS--------A 519

  Fly   298 TNLTP-------VFPHYSNRVVGCLLLNAHNLTSLEIWSFPFQALTWICLVFSFLSISCLALLHX 355
            ..:||       ....|.:..||.|:.......|:.....||....|.|:..:...:..|..:..
Human   520 ITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLN 584

  Fly   356 RGAGDRLALVLAVYAASLGLPIDPPERPS-----------------------------LQLLFAS 391
            |        :.||.|.|...|     |||                             ::::..|
Human   585 R--------IQAVRAQSAAQP-----RPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGS 636

  Fly   392 WLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDLTHGDYAAVMGRTTLQDLREVPSLQDLLGLK 456
            |.:|.|||.|.|:|.|...|............|||:.   ...|...|::|    .::.:....|
Human   637 WWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSK---QVEMSYGTVRD----SAVYEYFRAK 694

  Fly   457 SVIVTSEREE-----EVLRTL------DRCT------LREGAGSHPLFF---------GLISQDA 495
            .   |:..|:     |:.||:      |.|.      :|:....:..|.         .|...|.
Human   695 G---TNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDC 756

  Fly   496 LL-----HLTQRGHRAGAYH------IIPQDVLEQQ----LAIYLQK---H-------SHLASHL 535
            .:     .::.:|:.....|      :..|.:||.|    |.:..||   |       ||.::..
Human   757 SVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQA 821

  Fly   536 DHLVMSIRSVGLVHHWAGQMASERYFRSRFLYREKRIRQPDLWAVYILTAGLYLLSLV 593
            |...:.:      |.:||...                         ||..||.|..||
Human   822 DGKSLKL------HSFAGVFC-------------------------ILAIGLLLACLV 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		47/293 (16%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	45/282 (16%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	84/404 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954