DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7g and GRID1

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	773	Identity:	145/773 - (18%)
Similarity:	248/773 - (32%)	Gaps:	263/773 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VTSLLNFESMKYIGAQTQAASINHHVAQALRVFIEDFYQR----IAPAFIVVLSCRRPSPMNFYR 63
            ||.|...:.:.:..::.....:...:.||.|:.::...|:    |:..|..:.:..:...:|.||
Human   157 VTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYR 221

  Fly    64 NIMQ-------------LLYESVDT-------------------MIVQLVLVELGR---PRRI-- 91
            :.::             .:.|:|:|                   .|:.||...|||   .|:|
Human   222 DTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFP 286

  Fly    92 -------AGPRTHNL--LLVDSLDALLDI----EIHTYTAQSDTSEYYFIFLQQRDALIPHDMQG 143
                   .....|.:  ||.|..:..|.:    .::.|.:....:..:...|:.|.
Human   287 SAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRK--------- 342

  Fly   144 VFAYCWRHQLINCNVMTQS----SGGQVLLHT----YFPYAPG----QCNDSQP--------TRI 188
                 | |.:.:.|.:.:|    :||:.:|.|    :.....|    :.:.|.|        |..
Human   343 -----W-HSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTY 401

  Fly   189 NMFLGE------SWKHRDYFPSKLH------NLNGCPLIVLARKVSPFLDLDE---GQ-RELRGL 237
            :...|:      :|.........|.      .|.|..|.|:.....||:.:.|   || :..:|.
Human   402 SETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGF 466

  Fly   238 EGRLLQELSRRMNFSIQFSGLQD-----QLKNRTTWTEKQLLQKLVQERIAHLAIGYVRKRIQYA 297
            ...:|..|::.:.|..:.....|     ||.| |:|  ..::.:|:.:| |.|||.        |
Human   467 SIDVLDALAKALGFKYEIYQAPDGRYGHQLHN-TSW--NGMIGELISKR-ADLAIS--------A 519

  Fly   298 TNLTP-------VFPHYSNRVVGCLLLNAHNLTSLEIWSFPFQALTWICLVFSFLSISCLALLHX 355
            ..:||       ....|.:..||.|:.......|:.....||....|.|:..:...:..|..:.
Human   520 ITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLN 584

  Fly   356 RGAGDRLALVLAVYAASLGLPIDPPERPS-----------------------------LQLLFAS 391
            |        :.||.|.|...|     |||                             ::::..|
Human   585 R--------IQAVRAQSAAQP-----RPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGS 636

  Fly   392 WLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDLTHGDYAAVMGRTTLQDLREVPSLQDLLGLK 456
            |.:|.|||.|.|:|.|...|............|||:.   ...|...|::|    .::.:....|
Human   637 WWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSK---QVEMSYGTVRD----SAVYEYFRAK 694

  Fly   457 SVIVTSEREE-----EVLRTL------DRCT------LREGAGSHPLFF---------GLISQDA 495
            .   |:..|:     |:.||:      |.|.      :|:....:..|.         .|...|.
Human   695 G---TNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDC 756

  Fly   496 LL-----HLTQRGHRAGAYH------IIPQDVLEQQ----LAIYLQK---H-------SHLASHL 535
            .:     .::.:|:.....|      :..|.:||.|    |.:..||   |       ||.::..
Human   757 SVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQA 821

  Fly   536 DHLVMSIRSVGLVHHWAGQMASERYFRSRFLYREKRIRQPDLWAVYILTAGLYLLSLV 593
            |...:.:      |.:||...                         ||..||.|..||
Human   822 DGKSLKL------HSFAGVFC-------------------------ILAIGLLLACLV 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		47/293 (16%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	45/280 (16%)
		ANF_receptor	41..400	CDD:279440	42/257 (16%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	84/404 (21%)
		Lig_chan	564..841	CDD:278489	59/330 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840