Protein Alignment Ir7g and GRIA4

DIOPT Version :10

• Sequence 1: NP_001368933.1
• Gene: Ir7g / 31694
• FlyBaseID: FBgn0029968
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_000820.4
• Gene: GRIA4 / 2893
• HGNCID: 4574
• Length: 902
• Species: Homo sapiens
• Alignment Length: 721
• Identity: 131/721 - (18%)
• Similarity: 234/721 - (32%)
• Gaps: 206/721 - (28%)

  Fly     8 NFESMKYIGAQTQAASINHHVAQALRVFIEDFYQRIAPAFIVVLSCRRPSPMNFYRNIMQLL--- 69
            ||..:.|                  |..:|:..:|....|::.....|      .:||::.:
Human   188 NFNDVSY------------------RQLLEELDRRQEKKFVIDCEIER------LQNILEQIVSV 228

  Fly    70 ---YESVDTMIVQLVLVELGRPRRI-AGPRTHNLLLVD--------SLDALLDIEIHTYTAQSDT 122
               .:....:|..|...::...|.| .|.......|||        .:|....::...|.. |:|
Human   229 GKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPG-SET 292

  Fly   123 SEYYFIFLQQRDALIPHDMQGVFAYCWRHQLINCNVMTQSSGGQVLLHTYFPYAP-GQCNDSQPT 186
            ...|...|.....|:   |...|....|.::   ::..:.:.|..|.:   |.|| ||..|.:.|
Human   293 PPKYTSALTYDGVLV---MAETFRSLRRQKI---DISRRGNAGDCLAN---PAAPWGQGIDMERT 348

  Fly   187 ----RINMFLGE-SWKH--------RDYF------PSKLHNLNGCPLIVLARKV----------- 221
                ||....|. .:.|        .|.|      |.|:...|....:||.:.|
Human   349 LKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIE 413

  Fly   222 -----------SPFL------DLDEGQRELRGLEGRLLQELSRRMNFSIQFS-------GLQDQL 262
                       ||::      ::.||..:..|....|..|:::.:....:.:       |.:|
Human   414 NRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARD-- 476

  Fly   263 KNRTTWTEK--QLLQKLVQERIAHLAIGYVRKR-IQYATNLTPVFPHYSNRVVGCLLLNAHNLTS 324
            .:...|...  :|:....:..||.|.|..||:. |.::.      |..|..:  .:::.....:.
Human   477 ADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSK------PFMSLGI--SIMIKKPQKSK 533

  Fly   325 LEIWSF--PFQALTWICLVFSFLSISCLALLHXR----------------GAGDRLALVLAVYAA 371
            ..::||  |.....|:|:||:::.:|.:..|..|                |..|:......::.:
Human   534 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNS 598

  Fly   372 ---SLGLPID-----PPERPSLQLLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDL-- 426
               |||..:.     .|...|.:::...|..|.||:.|.|:|.|...|..........:.:||
Human   599 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 663

  Fly   427 -THGDYAAVMGRTTLQDLREVPSLQDLLGLKSVIVTSEREEEVLRTLDRC----TLREGAG---- 482
             |...|..:...:|.:..|           :|.|...|:....:|:.:..    |..||..
Human   664 QTEIAYGTLDSGSTKEFFR-----------RSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRK 717

  Fly   483 SHPLFFGLISQDALLHLTQRGHRAGAYHIIPQDVLE-------QQLAIYLQKHSHLASHLDHLVM 540
            |...|..|:......::.||.         |.|.::       :...:...|.|.|.:.::..|:
Human   718 SKGKFAFLLESTMNEYIEQRK---------PCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVL 773

  Fly   541 SIRSVGLVHHWAGQMASERYFRSRFLYREKRIRQPD---------------LWAVYILTAGLYLL 590
            .:...|::..          .::::.|.:......|               ....|||..||.|.
Human   774 KLSEAGVLDK----------LKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLA 828

  Fly   591 SLVVFI 596
            .||..|
Human   829 MLVALI 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
GRIA4	NP_000820.4	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	48/245 (20%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	72/420 (17%)