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Protein Alignment Ir7g and GRIA4

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	721	Identity:	131/721 - (18%)
Similarity:	234/721 - (32%)	Gaps:	206/721 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NFESMKYIGAQTQAASINHHVAQALRVFIEDFYQRIAPAFIVVLSCRRPSPMNFYRNIMQLL--- 69
            ||..:.|                  |..:|:..:|....|::.....|      .:||::.:
Human   188 NFNDVSY------------------RQLLEELDRRQEKKFVIDCEIER------LQNILEQIVSV 228

  Fly    70 ---YESVDTMIVQLVLVELGRPRRI-AGPRTHNLLLVD--------SLDALLDIEIHTYTAQSDT 122
               .:....:|..|...::...|.| .|.......|||        .:|....::...|.. |:|
Human   229 GKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPG-SET 292

  Fly   123 SEYYFIFLQQRDALIPHDMQGVFAYCWRHQLINCNVMTQSSGGQVLLHTYFPYAP-GQCNDSQPT 186
            ...|...|.....|:   |...|....|.::   ::..:.:.|..|.:   |.|| ||..|.:.|
Human   293 PPKYTSALTYDGVLV---MAETFRSLRRQKI---DISRRGNAGDCLAN---PAAPWGQGIDMERT 348

  Fly   187 ----RINMFLGE-SWKH--------RDYF------PSKLHNLNGCPLIVLARKV----------- 221
                ||....|. .:.|        .|.|      |.|:...|....:||.:.|
Human   349 LKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAAIE 413

  Fly   222 -----------SPFL------DLDEGQRELRGLEGRLLQELSRRMNFSIQFS-------GLQDQL 262
                       ||::      ::.||..:..|....|..|:::.:....:.:       |.:|
Human   414 NRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARD-- 476

  Fly   263 KNRTTWTEK--QLLQKLVQERIAHLAIGYVRKR-IQYATNLTPVFPHYSNRVVGCLLLNAHNLTS 324
            .:...|...  :|:....:..||.|.|..||:. |.::.      |..|..:  .:::.....:.
Human   477 ADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSK------PFMSLGI--SIMIKKPQKSK 533

  Fly   325 LEIWSF--PFQALTWICLVFSFLSISCLALLHXR----------------GAGDRLALVLAVYAA 371
            ..::||  |.....|:|:||:::.:|.:..|..|                |..|:......::.:
Human   534 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNS 598

  Fly   372 ---SLGLPID-----PPERPSLQLLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDL-- 426
               |||..:.     .|...|.:::...|..|.||:.|.|:|.|...|..........:.:||
Human   599 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 663

  Fly   427 -THGDYAAVMGRTTLQDLREVPSLQDLLGLKSVIVTSEREEEVLRTLDRC----TLREGAG---- 482
             |...|..:...:|.:..|           :|.|...|:....:|:.:..    |..||..
Human   664 QTEIAYGTLDSGSTKEFFR-----------RSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRK 717

  Fly   483 SHPLFFGLISQDALLHLTQRGHRAGAYHIIPQDVLE-------QQLAIYLQKHSHLASHLDHLVM 540
            |...|..|:......::.||.         |.|.::       :...:...|.|.|.:.::..|:
Human   718 SKGKFAFLLESTMNEYIEQRK---------PCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVL 773

  Fly   541 SIRSVGLVHHWAGQMASERYFRSRFLYREKRIRQPD---------------LWAVYILTAGLYLL 590
            .:...|::..          .::::.|.:......|               ....|||..||.|.
Human   774 KLSEAGVLDK----------LKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLA 828

  Fly   591 SLVVFI 596
            .||..|
Human   829 MLVALI 834

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.