Protein Alignment Ir7g and Grin3a

DIOPT Version :10

• Sequence 1: NP_001368933.1
• Gene: Ir7g / 31694
• FlyBaseID: FBgn0029968
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_612555.1
• Gene: Grin3a / 191573
• RGDID: 621704
• Length: 1135
• Species: Rattus norvegicus
• Alignment Length: 630
• Identity: 123/630 - (19%)
• Similarity: 184/630 - (29%)
• Gaps: 251/630 - (39%)

  Fly    85 LGRPRRIAGPRTHNLLLVDSLDALLDIEIHTYTAQSDTSEYYF--------------IFLQQRDA 135
            ||..:.:...||..|        .|.:..|..|.|| ..|||.              ..:|...|
  Rat   356 LGDSQNVEELRTEGL--------PLGLIAHGKTTQS-VFEYYVQDAMELVARAVATATMIQPELA 411

  Fly   136 LIPHDMQGVFAYCWRHQLINC-NVMTQS-SGGQ----VLLHTYFPYAPGQCNDSQPTRI----NM 190
            |:|..|             || :|.|.: :.||    .|.:|.|....|.......|.|    |.
  Rat   412 LLPSTM-------------NCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNF 463

  Fly   191 FLGE---------------SW-----------------KHRDYF--PSKLHNLNGCPLI----VL 217
            |:..               ||                 :|:.:|  |:||| |....||    |.
  Rat   464 FIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLH-LRVVTLIEHPFVF 527

  Fly   218 ARKVSPFLDLDEG-------------------QRELRGLEGR------------------LLQEL 245
            .|:|.     |||                   .|....|...                  ||::|
  Rat   528 TREVD-----DEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQL 587

  Fly   246 SRRMNFSIQF----SGLQDQLKNRTTWT--EKQLLQKLVQERIAHLAIGYVRKRIQYATNLTPVF 304
            :..|||....    .|.....|| ..||  ...||.......:...:|...|.::...|:
  Rat   588 AEDMNFDFDLYIVGDGKYGAWKN-GHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTS----- 646

  Fly   305 PHYSNRVVGCLLLNAHNLTSLEIWSFPFQALTWICL----------------------------- 340
            |.:|.. :|.|:........:..:.:|.....|:.:
  Rat   647 PFFSTS-LGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNR 710

  Fly   341 --VFSFLSI--SCLALLHXRGAGDRLALVLAVYAASLGLPIDPPERPSLQLLFASWLIFGLIVRS 401
              ||||.|.  .|.|||..|.|.                 |.||:..:.:.|...|.||.:...|
  Rat   711 NKVFSFSSALNVCYALLFGRTAA-----------------IKPPKCWTGRFLMNLWAIFCMFCLS 758

  Fly   402 MYSALLFFILRYHLHQRLPGNLQDLTHGDYAAVM-GRTTLQDLREV--PSL-QDLLGLKSVIVTS 462
            .|:|.|                        |||| |....::|..:  |.| ....|.:...|..
  Rat   759 TYTANL------------------------AAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRE 799

  Fly   463 EREEEVLR----TLDRCTLREGAGSHPLFFGLISQDALLHLTQRGHRAGAYHIIPQDVLEQQLAI 523
            ...|:.:|    .:.....|....:.|        |.:.:|.....:..|: |:.:.:|:.:::|
  Rat   800 SSAEDYVRQSFPEMHEYMRRYNVPATP--------DGVQYLKNDPEKLDAF-IMDKALLDYEVSI 855

  Fly   524 -----------------Y---LQKHSHLASHLDHLVMSIRSVGLV 548
                             |   |..:|.|.|::..|:...:|.|.:
  Rat   856 DADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFM 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	34/161 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..117
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	86/452 (19%)
		Lig_chan	674..941	CDD:459656	51/277 (18%)
		PPP2CB binding site. /evidence=ECO:0000269|PubMed:11588171	951..987
		GIT1-binding. /evidence=ECO:0000269|PubMed:24297929	1082..1115