DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7g and glr-4

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	704	Identity:	136/704 - (19%)
Similarity:	235/704 - (33%)	Gaps:	221/704 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NVTSLLNFESMKYIGAQTQAASINHHVAQALRVF-------IEDFYQRIAPAFIVVLSCRRPSPM 59
            |:|.|.|.        ..||..:|........||       :|||...:..|
Worm   224 NITVLYNL--------LQQARGLNMAEPPFSYVFTNTDLSLLEDFLNNMYGA------------- 267

  Fly    60 NFYRNIMQLLYESVDTMI----------VQLVLVELGRPRRIAGPRTHNLLLVDSLDALLDIEIH 114
            :|:.||..|.....|.|:          |.:|.:.:.|.|.:......:.::.||.|...|..|.
Worm   268 SFHCNITGLQLVKNDPMMKTQLALTSEAVYVVGMSIYRMRELGHAPRQSSIMCDSHDIWSDGRIM 332

  Fly   115 TYTAQSDTSEYYFIFLQQRDALIPHDMQGVFAYCWRHQLINCNVMTQSSG--GQVLLHTYFPYAP 177
            .                          :|:.....|:||.. :|..:|:|  ..::.|     ..
Worm   333 N--------------------------EGIRKLKLRNQLTG-DVQFKSNGERDDIMYH-----GV 365

  Fly   178 GQCNDSQPTRINMFLGESWKHRD--YFPSKLHN------------LNGCPLIVLARKVSPFLDLD 228
            |:.| ||..::.     :|..:.  .|.|:..|            |.|..|.|:.....||: :.
Worm   366 GRIN-SQFVKLG-----NWSEKRGWNFDSRYANRWEFDIDPDSEDLEGLHLRVVVYLEEPFV-IK 423

  Fly   229 EGQRELRGLEGRLLQELSRRMNFSIQF-------SGLQDQLKNRTTWTEKQLLQKLVQERIAHLA 286
            .|:.:..|....||.|:::.:.|:...       .|::|: ..|.......|.:......::.:.
Worm   424 TGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGIEDE-SGRWNGIIGALQRHEADLSLSAVT 487

  Fly   287 IGYVRKRIQYATNLTPVFPHYSNRVVGCLLLNAHNLTSLE-----IWSF--PFQALTWICLVFSF 344
            |.|.|..:   .:.|..|.|     :|..:|.|.  ||.|     :|:|  |.....||.|:.|:
Worm   488 ITYSRAEV---VDFTLPFMH-----LGISILLAR--TSEETDKGSLWTFLEPLSLTVWISLLISY 542

  Fly   345 LSIS----CLALL-----------------HXRGAGDRLALVLAVYAASLGLPIDP-----PERP 383
            ..:|    .||..                 : :...::.. ||..:..::|..:..     |...
Worm   543 CIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQKNQFT-VLNSFWFTMGSLMQQGSDVIPRAA 606

  Fly   384 SLQLLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDLTHGD---YAAVMGRTTLQDLRE 445
            :.:|:...|.:|..|:.|.|:|.|...|..........:.|||.:..   |..:...:|:...||
Worm   607 ATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLANQQKIRYGVLKSGSTMDFFRE 671

  Fly   446 VPSLQDLLGLKSVIVTSEREEEVLRTLDRCTLREGAGSHPLFFGLISQDALLHLTQRGHRAGAY- 509
                       |.|...||...|:.:           |.|..|...|::.:..:     ::|.|
Worm   672 -----------SKIPMYERMWSVMES-----------SSPGVFVNSSREGIARV-----KSGGYA 709

  Fly   510 HIIPQDVLEQQL------------------AIYLQKHSHLASHLDHLVMSI--RSV--GLVHHW- 551
            :::...:||..|                  .|.|.|.|.|...|...|:.:  |::  .|.:.|
Worm   710 YMMESSMLEYYLERDCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWW 774

  Fly   552 --------AGQMASERYFRSRFLYREKRIRQPDLWAV-YILTAGLYLLSLVVFI 596
                    .|...||:...|         :..:::.: |:|..||    :|.|:
Worm   775 RDRREGPSCGPPPSEKATNS---------KPQNIFGIFYVLLTGL----IVAFL 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	41/219 (19%)
		ANF_receptor	45..365	CDD:279440	36/193 (19%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	80/404 (20%)
		Lig_chan	533..810	CDD:278489	57/313 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910