DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7g and Grin3b

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006513350.1	Gene:	Grin3b / 170483	MGIID:	2150393	Length:	1138	Species:	Mus musculus

Alignment Length:	451	Identity:	96/451 - (21%)
Similarity:	167/451 - (37%)	Gaps:	126/451 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 ARKVSPFLDLDEGQ--RELR----GLEGRLLQELSRRMNFSIQ--------FSGLQDQLKNRTTW 268
            ||..:.|..|:.|.  |.||    |....||:.|:..:.|..:        :..|:|     ..|
Mouse   534 ARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRD-----GRW 593

  Fly   269 TEKQLLQKLVQERIAHLA-----IGYVRKRIQYATNLTPVFPHYSNRVVGCLLLNAHNLTSLEIW 328
            |  .|:..|:..| ||:|     |...|.::...|:     |.:|.. :|.::......:.:..:
Mouse   594 T--GLVGDLLAGR-AHMAVTSFSINSARSQVVDFTS-----PFFSTS-LGIMVRTRDTASPIGAF 649

  Fly   329 SFPFQALTWICLVFSFLSISCLALL------------HXRGAGDRLALVLAV---YAASLGLPID 378
            .:|.....|:. ||:.|.::.|.|.            ..|..|...:...|:   ||...|..:.
Mouse   650 MWPLHWSMWVG-VFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVS 713

  Fly   379 --PPERPSLQLLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDLTHGDYAAVM-GRTTL 440
              .|:.|:.:.|...|.||.|:|.|.|:|.|                        |||| |..|.
Mouse   714 SKTPKCPTGRFLMNLWAIFCLLVLSSYTANL------------------------AAVMVGDKTF 754

  Fly   441 QDLREV--PSL-QDLLGLKSVIVTSEREEEVLRT----LDRCTLREGAGSHPLFFGLISQDALLH 498
            ::|..:  |.| ....|.:...|.....|..::.    :.....|..|.:.|....:::.|.
Mouse   755 EELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDP--- 816

  Fly   499 LTQRGHRAGAYHIIPQDVLEQQLAI-----------------Y---LQKHSHLASHLDHLVMSIR 543
                 .:..|: |:.:.:|:.:::|                 |   |.::|.|.|:|...:...:
Mouse   817 -----PKLNAF-IMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYK 875

  Fly   544 SVGLVHHWAGQMASERYFRSRFLYREKRIRQPDLWAV-YILTAGLYLLS-LVVFICELLAS 602
            |.|.:     .:..::::  :.:...||:     :|| ..|..|:|.|| |.|.:|..|.|
Mouse   876 SSGFI-----DLLHDKWY--KMVPCGKRV-----FAVTETLQMGVYHLSGLFVLLCLGLGS 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	82/406 (20%)
		Lig_chan	656..922	CDD:365843	64/311 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846614
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840