DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7g and Grik1

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	703	Identity:	132/703 - (18%)
Similarity:	238/703 - (33%)	Gaps:	210/703 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LNFESMKYIGAQTQAASI----NHHVAQALRVFIEDFYQRIAPAFIVVLSCRRPSP-MNFYRNIM 66
            |:.|..:|.|.......:    |.||:..:..:..:..|  ||          |.| ......:|
Mouse   265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQ--AP----------PRPETGLLDGVM 317

  Fly    67 ----QLLYESVDTMIV------QLVLVEL----GRPRRIAGPRTHNLL---------------LV 102
                .|:|::|..:.:      ||.:..|    .:|.|: |||..||:               ..
Mouse   318 TTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRL-GPRFMNLIKEARWDGLTGRITFNKT 381

  Fly   103 DSLDALLDIEIHTYTAQSDTSEYYFIFLQQRDALIPHDMQGVFAYCWRHQLINCNVMTQSSGGQV 167
            |.|....|::|              |.|::..                         |:.:.|:|
Mouse   382 DGLRKDFDLDI--------------ISLKEEG-------------------------TEKASGEV 407

  Fly   168 LLHTYFPYAP-GQCNDSQPTRINMFLGESWKHRDYFPSKLHNLNGCPLIVLARKVSPFLDLDEGQ 231
            ..|.|..:.. |..|.:  :.:||..|    :||...:...:|....|||......|::...:..
Mouse   408 SKHLYKVWKKIGIWNSN--SGLNMTDG----NRDRSNNITDSLANRTLIVTTILEEPYVMYRKSD 466

  Fly   232 RELRG---LEG---RLLQELSRRMNFSIQFS-------GLQDQLKNRTTWTEKQLLQKLVQERIA 283
            :.|.|   .||   .||:|||..:.|.....       |.|:. |.......|:|:.......:|
Mouse   467 KPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQND-KGEWNGMVKELIDHRADLAVA 530

  Fly   284 HLAIGYVRKRIQYATNLTPVFPHYSNRVVG-CLLLNAHNLTSLEIWSF--PFQALTWICLVFSFL 345
            .|.|.|||:::   .:.:..|     ..:| .:|....|.|:..::||  |.....|:.::.:.|
Mouse   531 PLTITYVREKV---IDFSKPF-----MTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACL 587

  Fly   346 SISCLALLHXRGAGDRLALVLAVYAASLGLPIDP------------------------------P 380
            .:||:..:..|         ...|......|.:|                              |
Mouse   588 GVSCVLFVIAR---------FTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMP 643

  Fly   381 ERPSLQLLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDL---THGDYAAVMGRTTLQD 442
            :..|.:::...|..|.||:.|.|:|.|...|.....:....:..||   |..:|.||...:|:..
Mouse   644 KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTF 708

  Fly   443 LR--EVPSLQDLLGLKSVIVTSEREEEVLRTLDRCTLREGAGSHPLFFGLISQDALLHLTQR--- 502
            .:  ::.:.:.:....|    |.::..:::..|....|.....:.|   |:...::.::|||
Mouse   709 FKKSKISTYEKMWAFMS----SRQQSALVKNSDEGIQRVLTTDYAL---LMESTSIEYVTQRNCN 766

  Fly   503 -----------GHRAGAYHIIPQDVLEQQLAIYLQKHSHLASHLDHLVMSIRSVGLVHHWAGQMA 556
                       |:..|.....|          |..|       :...::.::..|.:|     |.
Mouse   767 LTQIGGLIDSKGYGVGTPIGSP----------YRDK-------ITIAILQLQEEGKLH-----MM 809

  Fly   557 SERYFRSRFLYRE-----KRIRQPDLWAVYILTAGLYLLSLVVFICELLASRR 604
            .|:::|......|     ..:...::..::|:.|...:||:.|.|.|.:...|
Mouse   810 KEKWWRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSR 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	41/219 (19%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	77/415 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846563
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930