DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7g and Grid1

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	781	Identity:	145/781 - (18%)
Similarity:	244/781 - (31%)	Gaps:	279/781 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VTSLLNFESMKYIGAQTQAASINHHVAQALRVFIEDFYQR----IAPAFIVVLSCRRPSPMNFYR 63
            ||.|...:.:.:..::.....:...:.||.|:.::...|:    |:..|..:.:..:...:|.||
Mouse   157 VTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYR 221

  Fly    64 NIMQ-------------LLYESVDT-------------------MIVQLVLVELGR---PRRIAG 93
            :.::             .:.|:|:|                   .|:.||...|||   .|:|..
Mouse   222 DTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFP 286

  Fly    94 PRTHN-----------LLLVDSLDALLDI----EIHTYTAQSDTSEYYFIFLQQRDALIPHDMQG 143
            ....|           .||.|..:..|.:    .::.|.:....:..:...|:.|.
Mouse   287 SAKDNQKCMRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRK--------- 342

  Fly   144 VFAYCWRHQLINCNVMTQS----SGGQVLLHT----YFPYAPG----QCNDSQP--------TRI 188
                 | |.:.:.|.:.:|    :||:.:|.|    :.....|    :.:.|.|        |..
Mouse   343 -----W-HSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTY 401

  Fly   189 NMFLGE------SWKHRDYFPSKLH------NLNGCPLIVLARKVSPFLDLDE---GQ-RELRGL 237
            :...|:      :|.........|.      .|.|..|.|:.....||:.:.|   || :..:|.
Mouse   402 SETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGF 466

  Fly   238 EGRLLQELSRRMNFSIQFSGLQD-----QLKNRTTWTEKQLLQKLVQERIAHLAIGYVRKRIQYA 297
            ...:|..|::.:.|..:.....|     ||.| |:|  ..::.:|:.:| |.|||.        |
Mouse   467 SIDVLDALAKALGFKYEIYQAPDGRYGHQLHN-TSW--NGMIGELISKR-ADLAIS--------A 519

  Fly   298 TNLTP-------VFPHYSNRVVGCLLLNAHNLTSLEIWSFPFQALTWICLVFSFLSISCLALLHX 355
            ..:||       ....|.:..||.|:.......|:.....||....|.|:..:...:..|..:..
Mouse   520 ITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLN 584

  Fly   356 RGAGDRLALVLAVYAASLGLPIDPPERPS-----------------------------LQLLFAS 391
            |        :.||.:.|...|     |||                             ::::..|
Mouse   585 R--------IQAVRSQSATQP-----RPSASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGS 636

  Fly   392 WLIFGLIVRSMYSALLFFILR-----------YHLHQRLP---GNLQDLTHGDYAAVMGRTTLQD 442
            |.:|.|||.|.|:|.|...|.           ..|.::|.   |.::|....:|....|...|:
Mouse   637 WWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLE- 700

  Fly   443 LREVPSLQDLLGLKSVIVTSEREEEVLRTL------DRCTLREGAGSHPL--------------- 486
                   ||           ....|:.||:      |.|......|....
Mouse   701 -------QD-----------STFAELWRTISKNGGADNCVSNPSEGIRKAKKGNYAFLWDVAVVE 747

  Fly   487 FFGLISQDALL-----HLTQRGHRAGAYH------IIPQDVLEQQ----LAIYLQK---HS---H 530
            :..|...|..:     .::.:|:.....|      :..|.:||.|    |.:..||   |:   .
Mouse   748 YAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHTGRCD 812

  Fly   531 LASHLDHLVMSIRSVG---LVHHWAGQMASERYFRSRFLYREKRIRQPDLWAVYILTAGLYLLSL 592
            |.||     .|.::.|   .:|.:||...                         ||..||.|..|
Mouse   813 LTSH-----SSTQTEGKSLKLHSFAGVFC-------------------------ILAIGLLLACL 847

  Fly   593 V 593
            |
Mouse   848 V 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		47/293 (16%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	45/280 (16%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	82/413 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846305
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840