DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7g and Gria4

DIOPT Version :9

Sequence 1:	NP_001368933.1	Gene:	Ir7g / 31694	FlyBaseID:	FBgn0029968	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	721	Identity:	131/721 - (18%)
Similarity:	235/721 - (32%)	Gaps:	206/721 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NFESMKYIGAQTQAASINHHVAQALRVFIEDFYQRIAPAFIVVLSCRRPSPMNFYRNIMQLL--- 69
            ||..:.|                  |..:|:..:|....|::.....|      .:||::.:
Mouse   188 NFNDVSY------------------RQLLEELDRRQEKKFVIDCEIER------LQNILEQIVSV 228

  Fly    70 ---YESVDTMIVQLVLVELGRPRRI-AGPRTHNLLLVD----SLDALLD----IEIHTYTAQSDT 122
               .:....:|..|...::...|.| .|.......|||    .:..|:|    ::...|.. |:|
Mouse   229 GKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPG-SET 292

  Fly   123 SEYYFIFLQQRDALIPHDMQGVFAYCWRHQLINCNVMTQSSGGQVLLHTYFPYAP-GQCNDSQPT 186
            ...|...|.....|:   |...|....|.::   ::..:.:.|..|.:   |.|| ||..|.:.|
Mouse   293 PPKYTSALTYDGVLV---MAETFRSLRRQKI---DISRRGNAGDCLAN---PAAPWGQGIDMERT 348

  Fly   187 ----RINMFLGE-SWKH--------RDYF------PSKLHNLNGCPLIVLARKV----------- 221
                ||....|. .:.|        .|.|      |.|:...|....:||.:..
Mouse   349 LKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIE 413

  Fly   222 -----------SPFL------DLDEGQRELRGLEGRLLQELSRRMNFSIQFS-------GLQDQL 262
                       ||::      ::.||..:..|....|..|:::.:....:.:       |.:|
Mouse   414 NRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARD-- 476

  Fly   263 KNRTTWTEK--QLLQKLVQERIAHLAIGYVRKR-IQYATNLTPVFPHYSNRVVGCLLLNAHNLTS 324
            .:...|...  :|:....:..||.|.|..||:. |.::.      |..|..:  .:::.....:.
Mouse   477 ADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSK------PFMSLGI--SIMIKKPQKSK 533

  Fly   325 LEIWSF--PFQALTWICLVFSFLSISCLALLHXR----------------GAGDRLALVLAVYAA 371
            ..::||  |.....|:|:||:::.:|.:..|..|                |..|:......::.:
Mouse   534 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNS 598

  Fly   372 ---SLGLPID-----PPERPSLQLLFASWLIFGLIVRSMYSALLFFILRYHLHQRLPGNLQDL-- 426
               |||..:.     .|...|.:::...|..|.||:.|.|:|.|...|..........:.:||
Mouse   599 LWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAK 663

  Fly   427 -THGDYAAVMGRTTLQDLREVPSLQDLLGLKSVIVTSEREEEVLRTLDRC----TLREGAG---- 482
             |...|..:...:|.:..|           :|.|...|:....:|:.:..    |..||..
Mouse   664 QTEIAYGTLDSGSTKEFFR-----------RSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRK 717

  Fly   483 SHPLFFGLISQDALLHLTQRGHRAGAYHIIPQDVLE-------QQLAIYLQKHSHLASHLDHLVM 540
            |...|..|:......::.||.         |.|.::       :...:...|.|.|.:.::..|:
Mouse   718 SKGKFAFLLESTMNEYIEQRK---------PCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVL 773

  Fly   541 SIRSVGLVHHWAGQMASERYFRSRFLYREKRIRQPD---------------LWAVYILTAGLYLL 590
            .:...|::..          .::::.|.:......|               ....|||..||.|.
Mouse   774 KLSEAGVLDK----------LKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLA 828

  Fly   591 SLVVFI 596
            .||..|
Mouse   829 MLVALI 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7g	NP_001368933.1	None
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	49/245 (20%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	72/420 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930