DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and grin3ba

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	725	Identity:	138/725 - (19%)
Similarity:	239/725 - (32%)	Gaps:	259/725 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PPPSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLEDQPMESLKIMFRRLL 146
            ||...:.|.|::   ||||.|          :|||     ..|:.|..:..:|           |
Zfish   277 PPMHWIMGYPLS---LDSLHS----------IGSP-----LGLMAYGEVNRKP-----------L 312

  Fly   147 NMYVLNVNVFLQRDGTVHLYTYYPYGPHHCQSSLPVYYTAFQDLA----------APANG----- 196
            |.|:        || |:.|.....|.....:..|.:    .|::.          .|::|
Zfish   313 NFYI--------RD-TLQLIGRAVYAATMVRPDLAL----IQNMVNCFDKPNKHELPSSGQYLAR 364

  Fly   197 -------FGLTKPL-----FPRKLTNMH------------------------------------- 212
                   .|||.|:     |.|.||:..
Zfish   365 FLSNTSFTGLTGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTVASWQSGRLELEEQGLWPG 429

  Fly   213 -------------------------GCEMVVATFEHRPYVI---IEDDPKTPGGR-----SIHGI 244
                                     |..:.|.|....|:|.   ::::.:.|.|:     ..:..
Zfish   430 VTQHQREDGPGIRLGGRWQAGLPVAGSRLRVVTLVEHPFVFTREVDEEGQCPAGQLCLDPQTNNS 494

  Fly   245 EGL--IFR---------------------------SLAERMNFTIKLVEQKDKNRGEILPDGNFT 280
            |.|  :||                           .|||.|:|...|....|...| ....|.::
Zfish   495 EVLNQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDLYIVGDGKYG-AWKGGRWS 558

  Fly   281 GILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISPMGRLTRPFRYIIWS 345
            |::..::.|..::....|..:.|||.::..::.:.|..:.::|.|..:.:|:|....|..:.:|.
Zfish   559 GLVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGILVRSKDTAAPIGAFMWPLHWSMWV 623

  Fly   346 CILVSLIFGFVLICLLKITALPGLRNLVLGRRNRLPFMG-------MWASLLG-GLALYNPQRNF 402
            .|.|:|....:.|.|.:..:..|   :....|||:....       .:|.|.| .:|...|:...
Zfish   624 GIFVALHITALFITLYEWNSPFG---MTPHGRNRIRVFSYSSALNLCYAILFGRTVASKTPKCWT 685

  Fly   403 ARYILVMWLLQTLILRAAYTGQLYLL------------LQDVEMRSP-----IKSLSEVLAKDYE 450
            .|:::.:|.:..|::.::||..|..:            :.||::..|     ..::.|..|:||.
Zfish   686 GRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVKLHHPSLGFRFGTVRESSAEDYV 750

  Fly   451 FRILPALRTIFKD-SMPTTNFHAVLSLEESLYRLRDEDDPGITVALLQPTVNQFDFRSGPNKRHL 514
            .:..|.:....:. :.|||        .:.:..|: .|.|.:...::...:..::.....:.:.|
Zfish   751 KKSFPEMHEYMRRFNKPTT--------PDGVSTLK-TDPPQLDAFIMDKALLDYEVSIDADCKLL 806

  Fly   515 TV------------LPDPLMTAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRV 567
            ||            ||   ..:|||          |.:...:....|.|    |..|..|:..:|
Zfish   807 TVGKPFAIEGYGIGLP---QNSPLT----------RNVSEYVSRYKSDG----YMDMLHDKWYKV 854

  Fly   568 ---SKR--RNLEPKPLSIWRLSGIFV-CCAG-----LYLV---ALIVFILEILTTNHR------- 611
               .||  ...|...:.|...||:|| .|.|     |.|:   |...|||..|....|
Zfish   855 VPCGKRVFAVTETLQMGIQHFSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRHQQRFKYWLHT 919

  Fly   612 --RLRRAFNV 619
              ::.||.|:
Zfish   920 SQKIHRAINM 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/98 (18%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	60/298 (20%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	35/192 (18%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	80/424 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740