DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7c and grin3a

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	510	Identity:	106/510 - (20%)
Similarity:	189/510 - (37%)	Gaps:	119/510 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 LFPRKLTNMHGCE---------MVVATFEHRPYVI---IEDDPKTPGGR---------------S 240
            ::|.|..:..|.:         .||...|| |:|.   ::|:...|.|:               .
Zfish   500 VWPNKRRSQPGADWRHSSRLHLRVVTLVEH-PFVFTRDVDDEGLCPAGQLCLDPLTNDTALLESL 563

  Fly   241 IHGIEGL------------------IFRSLAERMNFTIKLVEQKDKNRGEILPDGNFTGILKMMV 287
            ..|::|.                  :...|||.|.|...|....|...| ...:|.:||::..::
Zfish   564 FQGLQGANDTVPLEFKKCCYGYCIDLLEKLAEDMGFDFDLYIVGDGKYG-AYKNGRWTGLVGDLM 627

  Fly   288 DGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISPMGRLTRPFRYIIWSCILVSLI 352
            .|..:|....|..:.|||.::..::.:.|..:.::|.:..:.:|:|....|..:.:|..|.|||.
Zfish   628 SGAAHLAVTSFSINSARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWSMWLGIFVSLH 692

  Fly   353 FGFVLICLLKITALPGLRNLVLGRRNRLPFMG----MWASLLGGLALYNPQRNF-ARYILVMWLL 412
            ...|.:.|.:..:..|:......|.....|..    .:|.|.|..|...|.:.: .|:::.:|.:
Zfish   693 VTAVFLTLYEWKSPFGMTPRGRNRDRVFSFSSALNVCYAILFGRTAAIKPPKCWTGRFLMNLWAI 757

  Fly   413 QTLILRAAYTGQLYLL------------LQDVEMRSPIK-----SLSEVLAKDYEFRILPALRTI 460
            ..|...:.||..|..:            :.|.::..|.:     ::.|..|:||..:..|.:...
Zfish   758 FCLFCLSTYTANLAAVMVGEKTYEQLSGIHDPKLHHPSQGFRFGTVRESSAEDYVKKSFPEMHEY 822

  Fly   461 FKD-SMPTTNFHAVLSLEESLYRLRDEDDPGITVALLQPTVNQFDFRSGPNKRHLTVLPDPLMTA 524
            .:. :.|||        .:.:..|:  |||....|.:.... ..|:.:..:| ::::|
Zfish   823 MRRYNAPTT--------PDGIDHLK--DDPQKLDAFIMDKA-LLDYWAHADKXYISLL------- 869

  Fly   525 PLTFY---MRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRV---SKR--RNLEPKPLSIW 581
             ||.|   ::.:|.....|..|:....|.|    :..|..|:..:|   .||  ...|...:.|.
Zfish   870 -LTGYGIGLKQNSPLTSNISELVSQYKSDG----FMDMLHDKWYKVVPCGKRSFAVTETLQMGIK 929

  Fly   582 RLSGIFV-CCAGLYLVALIVFILEIL----------TTNHR-------RLRRAFN 618
            ..||:|| .|.|:.|..|......|:          :|.|:       ||.||.|
Zfish   930 HFSGLFVMLCVGVALSLLTTLGEHIVHRWVIPRMQESTEHKYWLHTSQRLHRALN 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/97 (19%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	59/281 (21%)
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	0/1 (0%)
		ANF_receptor	132..452	CDD:279440
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	82/414 (20%)
		Lig_chan	682..941	CDD:278489	59/281 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740