DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7c and grik4

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	487	Identity:	105/487 - (21%)
Similarity:	191/487 - (39%)	Gaps:	80/487 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 RDGTVHLYTYYPYGPHHCQSSLPVYYTAFQDLAAPANGFGLTKPLFPRKLTNMHGCEMVVATFEH 223
            |||...:      |..|.:..|.:      :...|:  ..:|..||...||        :.|...
Zfish   383 RDGLRQI------GQWHSEQGLSM------ERKLPS--LNVTDTLFNTTLT--------ITTILE 425

  Fly   224 RPYVIIEDDPKTPGGRSIHGIEGL---IFRSLAERMNFTIKLVEQKDKNRGEILPDGNFTGILKM 285
            .|||::..:.:...|...:  ||.   :.:.||:.:.|..::....|...|....:|.:||::..
Zfish   426 NPYVMLRANHQELEGNDRY--EGFCVDMLKELADILKFKYRIRLVGDGVYGVPGANGTWTGMVGE 488

  Fly   286 MVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLV--VPSG---GSISPMGRLTRPFRYIIWS 345
            ::..:.:|.......:..|..::..|..:.:..|.::  |..|   |..|    ...||...:|.
Zfish   489 LISRKADLAVAALTITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYFS----FLDPFSPGVWL 549

  Fly   346 CILVS-LIFGFVLICLLKIT---------ALPGLRNLVLGRRNRLPFMG--MWASLLGGL----A 394
            .:|:: |....||..:.::|         .|.|..:|::.:.:    :|  .|.. :||.    :
Zfish   550 FMLLAYLAVSCVLFLVARLTPYEWYNPHPCLKGRCSLLINQYS----LGNSFWFP-VGGFMQQGS 609

  Fly   395 LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKS---LSEVLAKDYEFRILPA 456
            ...|:....|.:..:|...|||:.::||..|...|....|..||:|   |::..|.:|......:
Zfish   610 TIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGS 674

  Fly   457 LRTIFKDSMPTT-----NFH-------AVLSLEESLYRLRDEDDPGITVALLQPTVNQFDFRSGP 509
            ..|.|::|...|     ||.       .|.|.||.:.|:.:.:    ...||:.|:|::..:...
Zfish   675 TMTFFQNSRYQTYQRMWNFMYSKQPSVFVKSTEEGIARVLNSN----YAYLLESTMNEYYRQRNC 735

  Fly   510 NKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRVSKRRNLE 574
            |   ||.:...|.|......|...|.::...|..|:.:.....:...::.:.|..| ..|..:..
Zfish   736 N---LTQIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWWDGGK-CPKEEDHR 796

  Fly   575 PKPLSIWRLSGIFVCCAGLYLVALIVFILEIL 606
            .|.|.:..:.||||......|||:.:.:||.:
Zfish   797 AKGLGMENIGGIFVVLVCGLLVAIFMAVLEFV 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	14/64 (22%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	63/280 (23%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	6/22 (27%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	78/377 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740