DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and Ir93a

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_650924.3	Gene:	Ir93a / 42471	FlyBaseID:	FBgn0259215	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	134/732 - (18%)
Similarity:	256/732 - (34%)	Gaps:	176/732 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHSAVHN-VSLVYALVWAI-DNYYGMATSTPL--AVVQF-PTSRESRR--------LHNDLIDA 52
            ::|.::.| ::.:..:::.| |:..|......|  |:.|| |...|..|        .|.|:|:.
  Fly   185 IVHESITNHITPISLILYEINDSLRGQQKRVALRQALSQFAPKKHEEMRQQFLVISAFHEDIIEI 249

  Fly    53 A-------------------LGRSSGTGRIQFLLEDD-RVEMTETDTDPPPPSGL--TGRPIAIW 95
            |                   :.|....|.:...|::. .:.....:|||.....|  |...|::.
  Fly   250 AETLNMFHVGNQWMIFVLDMVARDFDAGTVTINLDEGANIAFALNETDPNCQDSLNCTISEISLA 314

  Fly    96 FLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLEDQPMESLKIMFRRLLNMYVLNVNVFL--- 157
            .:::: |...:|..               .||..:.|:..|:::...:......:..:..||
  Fly   315 LVNAI-SKITVEEE---------------SIYGEISDEEWEAIRFTKQEKQAEILEYMKEFLKTN 363

  Fly   158 ------------------------------QRDGTVHLYTYYPYGPHHCQSSLPVYYTAFQDLAA 192
                                          |||.....:.:...|          |:|
  Fly   364 AKCSSCARWRVETAITWGKSQENRKFRSTPQRDAKNRNFEFINIG----------YWT------- 411

  Fly   193 PANGFGLTKPLFPRKLTNMHGCEMVVATFEHRPYVIIEDDPKTPGGRSIH--GIEGLIFRSLAER 255
            |..||...:..||....:.....|.:.|..:.|:.|:   .|...|..:.  ||...|.:.|:..
  Fly   412 PVLGFVCQELAFPHIEHHFRNITMDILTVHNPPWQIL---TKNSNGVIVEHKGIVMEIVKELSRA 473

  Fly   256 MNFTIKLVEQ---KDKNRGEILPDGN----FTGILKM--------MVDGEVNLTFVCFMYSKARS 305
            :||:..|.|.   |:::.......||    ..|.:..        ||.|  |..|:..:.:....
  Fly   474 LNFSYYLHEASAWKEEDSLSTSAGGNESDELVGSMTFRIPYRVVEMVQG--NQFFIAAVAATVED 536

  Fly   306 DLMLPSTSYTSFPIVL-----VVPSGGSISPMGRLTRPFRYIIWSCILVSLIFGFVLI---CLLK 362
            ....| .:||. ||.:     :......:|.:...|.||....|.|::     |.:|:   .|..
  Fly   537 PDQKP-FNYTQ-PISVQKYSFITRKPDEVSRIYLFTAPFTVETWFCLM-----GIILLTAPTLYA 594

  Fly   363 ITALPGLRNL-VLGRRN-RLPFMGMWASLLGGLALYNPQRNFARYILVMWLLQTLILRAAYTGQL 425
            |..|..|:.: ::|... :..|..::.:||....:|.|..:..|.::..|.:..::|...|.|.|
  Fly   595 INRLAPLKEMRIVGLSTVKSCFWYIFGALLQQGGMYLPTADSGRLVVGFWWIVVIVLVTTYCGNL 659

  Fly   426 YLLLQDVEMRSPIKSLSEVLAKDYEFRILPALR--TIFKDSMPTT---NFHAVLSLEESLYRLRD 485
            ...|...:.:..:..|:::  :|::..:...||  |.|:..:.:|   :|...|. ...:|....
  Fly   660 VAFLTFPKFQPGVDYLNQL--EDHKDIVQYGLRNGTFFERYVQSTTREDFKHYLE-RAKIYGSAQ 721

  Fly   486 EDDPGITVALLQPTVNQFDFR-----------SGPNKRHLTVLPDPLMTAPLTFYMRPHSYFKRR 539
            |:|  |........:| .|:|           ....:.|..:..:..:...:...:...|.:...
  Fly   722 EED--IEAVKRGERIN-IDWRINLQLIVQRHFEREKECHFALGRESFVDEQIAMIVPAQSAYLHL 783

  Fly   540 IDRLIMAMMSSGIVARYRKMYM---DRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVF 601
            ::|.|.:|...|.:.|:.:|.:   .:....|.:|.:....:::..:.|.|       ||.|:.|
  Fly   784 VNRHIKSMFRMGFIERWHQMNLPSAGKCNGKSAQRQVTNHKVNMDDMQGCF-------LVLLLGF 841

  Fly   602 ILEILTTN----HRRLR 614
            .|.:|...    :||.|
  Fly   842 TLALLIVCGEFWYRRFR 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	16/78 (21%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	49/273 (18%)
Ir93a	NP_650924.3	Periplasmic_Binding_Protein_Type_2	429..>697	CDD:328725	59/281 (21%)
Ir93a	NP_650924.3	Lig_chan	576..836	CDD:306551	49/277 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840