DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and Ir75d

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_649074.2	Gene:	Ir75d / 40065	FlyBaseID:	FBgn0036829	Length:	675	Species:	Drosophila melanogaster

Alignment Length:	764	Identity:	151/764 - (19%)
Similarity:	243/764 - (31%)	Gaps:	292/764 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 HSAVHNVSLVYA----------LVWA---IDNYYGMATSTPLAVVQFPTSRESRRL-HNDLIDAA 53
            |..||::.||..          .:|.   ::|:|          ||..|....|.| |.|.:|
  Fly    56 HHGVHSLMLVVCHTDIADFRLWKLWQHFNLNNFY----------VQVSTESSLRDLQHVDALD-- 108

  Fly    54 LGRSSGTGRIQFLLEDDRVEMTETDTDPPPPSGLTGRPIAIW---FLDSLRSY--------FRLE 107
                                   ...|.|||..........|   ||.....|        |..|
  Fly   109 -----------------------EHKDAPPPKSFHANNSTHWETSFLLPALPYKMGILLLEFSSE 150

  Fly   108 MYLNQL-------GSPYKRNGFFLVIYTG------LEDQPMESLKIMFRRLLNMYVLNVNVFLQR 159
            ..||.|       .:.:..|.|:|::...      |||.                    .:|:..
  Fly   151 CALNLLRWSAASEHNYFTTNRFWLLLTEDPGDIDLLEDP--------------------EIFIPP 195

  Fly   160 DGTVHLYTYYPYGPHHCQSSLPVYYTAFQDLAAPANGFGLTKPLFPRKLT--NMHGCEMVVATFE 222
            |..:.:..|...|...| |.:.:|..|            ..||| .|.|.  |:.....|:...:
  Fly   196 DSELRVLHYENVGNFSC-SLIDLYKVA------------AWKPL-KRTLVGHNIRNSRHVIHALQ 246

  Fly   223 HRPYVIIEDDPKTPGGRSI---HGIEGLIFRS--------------------------------- 251
            |             .|.:|   ..:||::|.|
  Fly   247 H-------------FGSAITYRQDLEGIVFNSAIVIAFPDLFTNIEDLSLRHIDTISKVNHRLML 298

  Fly   252 -LAERMNFTIKLVEQKDKNRGEILPDGNFTGILK---------------MMVDGEVNLTFVCFMY 300
             ||.|:|.:....:  ..|.|...|:|:|.|::.               |.:|....:.||...|
  Fly   299 ELANRLNMSYNTYQ--TVNYGWRQPNGSFDGLMGRFQRYELDLAQLAIFMRLDRIALVDFVAETY 361

  Fly   301 SKARSDLMLPSTSYTSFPIVLVVPSGGSISPMGRLTRPFRYIIWSCILVSLIFGFVLICLLKITA 365
             :.|:.:|     :...|:..|    .:|..|     ||...:|..||:.||...|:: :|::..
  Fly   362 -RVRAGIM-----FRQPPLSAV----ANIFAM-----PFENDVWVSILMLLIITTVVL-VLELFF 410

  Fly   366 LPGLRNLVLGRRNRLPFMGMWASLLGGLALYNPQRN-FARYILVMWLLQTLILRAAYTGQLYLLL 429
            .|  .|..:...:.|.|  :|.::. ....|...|| .||.|:....:..|.|..:::..:..||
  Fly   411 SP--HNHDMSYMDTLNF--VWGAMC-QQGFYVEVRNRSARIIVFTTFVAALFLFTSFSANIVALL 470

  Fly   430 QDVEMRSP---IKSLS-------EVLAKDYEFRILPALRTIFKDSM-PTTN--FH-AVLSLEESL 480
            |     ||   |:|||       |:..:|.::.     :..|.:|. |.|.  :| .:.|..|::
  Fly   471 Q-----SPSDAIQSLSDLGQSPLEIGVQDTQYN-----KIYFTESTDPVTKNLYHKKIASKGENI 525

  Fly   481 YRLRDEDDPGITVALLQPTVNQFDFRSG---------------------PNKRHLTVLPDPLMTA 524
            |              ::|.:.....|:|                     |.|..|..| :|....
  Fly   526 Y--------------MRPLLGMEKMRTGLFAYQVELQAGYQIVSDTFSEPEKCGLMEL-EPFQLP 575

  Fly   525 PLTFYMRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRVSKRRNLEPKP---------LSI 580
            .|....|.:..:|..|.|.:.......:|.|            .:|:.:..||         :||
  Fly   576 MLAIPTRKNFPYKELIRRQLRWQREVSLVNR------------EERKWIPQKPKCEGGVGGFVSI 628

  Fly   581 ------WRLSGIFVCCAGLYLVALIVFILEILTTNHRRLRRAFNVINRY 623
                  :.| |||.|.|.   |:.::|:.|.:   .|..::.:.:|..|
  Fly   629 GITECRYAL-GIFGCGAA---VSFVLFLFEFI---FRHFKQVYRIIKGY 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	17/113 (15%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	65/300 (22%)
Ir75d	NP_649074.2	Periplasmic_Binding_Protein_Type_2	299..>483	CDD:304360	52/211 (25%)
Ir75d	NP_649074.2	Lig_chan	388..644	CDD:278489	64/299 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830