Protein Alignment Ir7c and GluRIIA

DIOPT Version :10

• Sequence 1: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Alignment Length: 713
• Identity: 141/713 - (19%)
• Similarity: 245/713 - (34%)
• Gaps: 229/713 - (32%)

  Fly     1 MLHSAVHNVSL--VYALVWAIDNYYGMATSTPLAVVQF-PTSRESRRLHNDLIDAALGRSSGTGR 62
            :.|...||..|  :|.     :::....||..|.||.. |..|:..||..  :|..||..:   .
  Fly   251 LTHLDTHNSGLRDIYN-----EDFKANITSVRLKVVDANPFERKKTRLTK--VDQILGNQT---M 305

  Fly    63 IQFLLEDDRVEMTETDTD-----PP--PPSGLTGRPIAIWFL-------------DSLRSYFRLE 107
            :..|:.|..|....:..:     .|  ||:...|.. :.|.|             |.:..:|:.|
  Fly   306 LPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSS-SPWMLGAFIVNEMKTISEDDVEPHFKTE 369

  Fly   108 -MYLNQLGSPYKRNGFFLVIYTGLEDQPM------ESLKIMFRRLLNMYVLNVNVFLQRDGTVHL 165
             |.|::.|   :|..|.|.||....::||      ..:|   :||||:.       |:..||.
  Fly   370 NMKLDEYG---QRIHFNLEIYKPTVNEPMMVWTPDNGIK---KRLLNLE-------LESAGTT-- 419

  Fly   166 YTYYPYGPHHCQSSLPVYYTAFQDLAAPANGFGLTKPLFPRKLTNMHGCEMVVATFEHRPYVIIE 230
                                  ||.:.            .||:       ..|.|....||.:::
  Fly   420 ----------------------QDFSE------------QRKV-------YTVVTHYEEPYFMMK 443

  Fly   231 DDPKTPGGRSIHGIEGL---IFRSLAERMNFTIKLVEQKDKNRGEILPD-GNFTGILKMMVD--- 288
            :|.:...||..:  ||.   :...|:|.|.|..:.:..  ...|:..|: ..:.||::.::|
  Fly   444 EDHENFRGREKY--EGYAVDLISKLSELMEFDYEFMIV--NGNGKYNPETKQWDGIIRKLIDHHA 504

  Fly   289 --GEVNLTF-----------VCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISPMGRLT--RP 338
              |..:||.           |.||      .|.:....|.|.|           .|..:..  .|
  Fly   505 QIGVCDLTITQMRRSVVDFTVPFM------QLGISILHYKSPP-----------EPKNQFAFLEP 552

  Fly   339 FR-----YIIWSCILVSLIFGFVLICLLKITALPGLRNLVLGRRNRLP----------FMGMW-- 386
            |.     |:|::.::::|.|.|:               ..|..|..||          ...:|
  Fly   553 FAVEVWIYMIFAQLIMTLAFVFI---------------ARLSYREWLPPNPAIQDPDELENIWNV 602

  Fly   387 ---ASLLGGLALYN-----PQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSE 443
               ..|:.|..:..     |:....|.:..||....|::.:.||..|...|...:.:|.||||.:
  Fly   603 NNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQD 667

  Fly   444 VLAK-----------------------DYEFRILPALRTIFKDSMPTTNFHAVLSLEESLYRLRD 485
            ::.:                       ||: |....::.....:..:||       :|.:.|:|.
  Fly   668 LIEQDKVHFGSMRGGSTSLFFSESNDTDYQ-RAWNQMKDFNPSAFTSTN-------KEGVARVRK 724

  Fly   486 EDDPGITVALLQPTVNQFDFRSGPNKRHLTVLPDPL------MTAPLTFYMRPHSYFKRRIDRLI 544
            |  .|....|::.|...::.....:   ||.:.:.:      :..||      .|.::..:...|
  Fly   725 E--KGGYAFLMETTSLTYNIERNCD---LTQIGEQIGEKHYGLAVPL------GSDYRTNLSVSI 778

  Fly   545 MAMMSSGIVARYR-KMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEIL 606
            :.:...|.:.:.: |.:.:..........::...|||..|.|:|:..||..|:.:|:.|.|.|
  Fly   779 LQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFL 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	15/65 (23%)
		Lig_chan	343..592	CDD:459656	51/298 (17%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	39/167 (23%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	79/431 (18%)
		Lig_chan	555..828	CDD:459656	53/306 (17%)