DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and GluRIIC

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster

Alignment Length:	676	Identity:	130/676 - (19%)
Similarity:	220/676 - (32%)	Gaps:	196/676 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SLVYALVWAIDNYYGMATSTPLAVVQFPTSRESRRLHNDLIDAALGRSSGTGRIQFLLEDDRVEM 74
            ||.|..|...||            :.:.:|...|.|.:|||..||...:.:.|.......||:.:
  Fly   282 SLPYGYVTQRDN------------IVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVV 334

  Fly    75 TETDTDPPPPSGLT---GRPIAIWFLDSL---RSYFRLEMYLNQLGSPYKRNGFFLVIYTGLEDQ 133
            .....|.....|.|   ||.:|.....:.   .:.||..:.  |.....:|..|.:.:|     .
  Fly   335 PRITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSIL--QFDEDGQRITFNIEVY-----D 392

  Fly   134 PMESLKIMF---RRLLNMYVLNVNVFLQRDGTVHLYTYYPYGPHHCQSSLPVYYTAFQDLAAPAN 195
            |::.:.|..   |..:..  |||:|..|:.....:.|  ..||.         |.::.:.|...|
  Fly   393 PLDGIGIAIWDPRGQITQ--LNVDVKAQKKMIYRVAT--RIGPP---------YFSYNETARELN 444

  Fly   196 GFGLTKPLFPRKLTNMHGCEMVVATFEHRPYVIIEDDPKTPGGRSIHGIEGLIFRSLAERMNFTI 260
                        ||                           |.....|....:..::|..:.|..
  Fly   445 ------------LT---------------------------GNALYQGYAVDLIDAIARHVGFEY 470

  Fly   261 KLVEQKDKNRGEILPD-GNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVV 323
            ..|...|:..|::..: ..:.||:..:::.:.::.......::||...:..:..:....: :|..
  Fly   471 VFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAY 535

  Fly   324 PSGGSISPMGRLTRPFRYIIWSCILVSLIFGFVLICLLKITAL----------PGLRN-LVLGRR 377
            .|......:.....||...:|..||:|:   ||:..|..|.|.          |..|: .||..:
  Fly   536 KSPHVEKTLDAYLAPFGGEVWIWILISV---FVMTFLKTIVARISKMDWENPHPCNRDPEVLENQ 597

  Fly   378 NRLPFMGMW---ASLLGGLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIK 439
            .|:...| |   ||::.......|:....|.....|.:..:|:..:||..|...|...:|...|.
  Fly   598 WRIHNTG-WLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIA 661

  Fly   440 SLSEVLA-KDYEFRILPALRTIFKDSMPTTNFHAVLSLEESLYR----LRDEDDP---------- 489
            :|.::.| |..:|      .||:..|    .::.:....|::||    |.:.|||
  Fly   662 NLKDLSAQKKVKF------GTIYGGS----TYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEG 716

  Fly   490 --------GITVALLQPTVNQF------DFRSGPNK---RHLTVLPDPLMTAPLTFYMRPHSYFK 537
                    |..:.|::.|..::      |.||...|   :|..:      ..|..
  Fly   717 VDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAI------AVPFG---------- 765

  Fly   538 RRIDRLIMAMMSSGIVARYRKMYMDRIKRVSKRRNL-----------------EPKP-----LSI 580
                            |.||......|.::|:|..|                 ||.|     ::.
  Fly   766 ----------------AEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTF 814

  Fly   581 WRLSGIFVCCAGLYLVALIVFILEIL 606
            ..|.|||.......|:|.::.|.|.|
  Fly   815 EELRGIFYTLYAGILIAFLIGITEFL 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	9/62 (15%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	65/317 (21%)
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	31/140 (22%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	23/92 (25%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	81/466 (17%)
		Lig_chan	554..828	CDD:278489	65/319 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840