DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and Ir11a

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_572795.2	Gene:	Ir11a / 32189	FlyBaseID:	FBgn0030385	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	136/540 - (25%)
Similarity:	233/540 - (43%)	Gaps:	88/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 KRNGFFLVIYTGLEDQPM--ESLKIMFRRLLNMYVLNVNVFLQ-RDGTVHLYTYYPYGPHHCQSS 179
            :|..|.:|:.:.::.:..  :::..:.:..|.|:.:||.|..| .||||..|:|..: ..:|...
  Fly   142 EREFFCIVVVSEIQSRQFVRQTVGSIVKSNLQMHFVNVVVVAQLEDGTVGTYSYKLF-KANCTPG 205

  Fly   180 LPVYYTAFQDLAAPANGFG-LT-KP------LFPRKLTNMHGCEMVVATFEHRPYVIIE--DDPK 234
            :.|         ...|.|. :| ||      |:|.:..::..|...|......|::|.:  .||.
  Fly   206 ITV---------RQINHFDRITGKPQQSMPDLYPVRNGHLGDCPFNVGAAHMPPHLIYKRHKDPP 261

  Fly   235 TPGGRSI-----HGIEGLIFRSLAERMNFTIKLVEQKDKNRGEILPDGNFTGILKMMVDGEVNLT 294
            .....||     .||:..:.:.||:.:.|.|:|...::.:  :|..:||.:|..:.:.||.|::.
  Fly   262 PASNVSIPAEDLAGIDWDLLQLLAKALKFRIQLYMPQEPS--QIFGEGNVSGCFRQLADGTVSIA 324

  Fly   295 FVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISPMGRLTRPFRYIIWSCILVSLIFGFVLIC 359
            ......|..|..|...||.|.....|:||.....:..:|.|..|||..:|..|:|.|:...:..|
  Fly   325 IGGLSGSDKRRSLFSKSTVYHQSNFVMVVRRDRYLGRLGPLILPFRGKLWGVIIVILLLAVLSTC 389

  Fly   360 LLKIT-----ALPGLRNLVLGRRNRLPFMGMWASLLGGLALYNPQRNFARYILVMWLLQTLILRA 419
            .|:..     .:..|..:::|  |.:|...:            |.:.|.||:|..|:|.||:||.
  Fly   390 WLRSRLGLSHPIEDLLTVIVG--NPIPDHRL------------PGKGFLRYLLASWMLLTLVLRC 440

  Fly   420 AYTGQLYLLLQDVEMRSPIKSLSEVLAKDYEFRILPALRTIFKDSMPTTNFHAVLSLEESLYRLR 484
            ||..:|:.:|:....|...|.||.::..:|              :|....:|....||.:..:..
  Fly   441 AYQARLFDVLRLSRHRPLPKDLSGLIKDNY--------------TMVANGYHDFYPLELTCRQPL 491

  Fly   485 D------------EDDPGITVALLQPTVNQFDFRSGPNKRHLTVLPDPLMTAPLTFYMRPHSYFK 537
            |            .|:...|:||:....  :.....||...||.:..|:....|..|. |..:|.
  Fly   492 DFSARFERVQRAAPDERLTTIALISNLA--YWNHKHPNISRLTFVRQPIYMYHLVIYF-PRRFFL 553

  Fly   538 R-RIDRLIMAMMSSGIVARYRKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCA----GLYLV- 596
            | .|||.|..::|:|::|...:.||   :..:||:.....|:.:.|::...:..|    ||.:|
  Fly   554 RPAIDRKIKQLLSAGVMAHIERRYM---QYENKRKVASNDPVLLRRITKSIMNGAYRIHGLVIVL 615

  Fly   597 ALIVFILEILT-TNHRRLRR 615
            |..:||||:|. .::.||||
  Fly   616 ATGMFILELLAGRSNGRLRR 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	17/68 (25%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	63/271 (23%)
Ir11a	NP_572795.2	Periplasmic_Binding_Protein_Type_2	306..>356	CDD:304360	15/49 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007621
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42643
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010