DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7c and Grik3

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001106187.1	Gene:	Grik3 / 298521	RGDID:	71027	Length:	919	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	119/492 - (24%)
Similarity:	185/492 - (37%)	Gaps:	113/492 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 APANGFGLTK------PLFPRKLTNMHGCEMVVATFEHRPYVIIEDDPKTPGGRSIHGIEGL--- 247
            :||:|..:|:      |.....|||.   .::|.|....|:|:.....:|..|..  ..||.
  Rat   409 SPADGLNITEVAKGRGPNVTDSLTNR---SLIVTTLLEEPFVMFRKSDRTLYGND--RFEGYCID 468

  Fly   248 IFRSLAERMNFT--IKLVE------QKDKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKAR 304
            :.:.||..:.|:  |:|||      |.||        |.:.|::|.::|.:.:|.......:..|
  Rat   469 LLKELAHILGFSYEIRLVEDGKYGAQDDK--------GQWNGMVKELIDHKADLAVAPLTITHVR 525

  Fly   305 SDLMLPSTSYTSFPIVLVV--PSGGSISPMGRLTRPFRYIIWSCILVSLIFGFVLICLLKITAL- 366
            ...:..|..:.:..:.::.  |:|.:.|....| .|....||..:|::.:   .:.|:|.:.|.
  Rat   526 EKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFL-NPLSPDIWMYVLLAYL---GVSCVLFVIARF 586

  Fly   367 ------------PGL----RNLVLGRRNRLPFMGMWASLLGGLALYNPQRNFARYILVMWLLQTL 415
                        ||.    .|..|  .|...| ||.:.:..|..|. |:....|.|..:|...||
  Rat   587 SPYEWYDAHPCNPGSEVVENNFTL--LNSFWF-GMGSLMQQGSELM-PKALSTRIIGGIWWFFTL 647

  Fly   416 ILRAAYTGQLYLLLQDVEMRSPIKSLSEVLAKD--YEFRILP--ALRTIFKDSMPTT--NFHAVL 474
            |:.::||..|...|....|.|||.|..: |||.  .|:..:.  |..|.||.|..:|  ...|.:
  Rat   648 IIISSYTANLAAFLTVERMESPIDSADD-LAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM 711

  Fly   475 SLEESLYRLRDEDDPGITVALLQPTVNQFDFRSGPNKRHLTVLPDPLMTAPLTFYMRPHSYFKRR 539
            |.:.|  .|...::.||                   :|.||.....||.:....|:...:....:
  Rat   712 SSKPS--ALVKNNEEGI-------------------QRTLTADYALLMESTTIEYITQRNCNLTQ 755

  Fly   540 IDRLIMAMMSSGIVARYRKMYMDRIK------------RVSKRR-----------NLEPKPLSIW 581
            |..||.: ...||.......|.|:|.            .:.|.:           |.|...|.|.
  Rat   756 IGGLIDS-KGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQ 819

  Fly   582 RLSGIF-VCCAGLYLVALIV---FILEILTTNHRRLR 614
            ::.||| |..|||.|..|:.   ||.::..|..|..|
  Rat   820 KIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQR 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	19/72 (26%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	72/296 (24%)
Grik3	NP_001106187.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	3/7 (43%)
		ANF_receptor	55..398	CDD:279440
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	94/411 (23%)
		Lig_chan	564..832	CDD:278489	72/297 (24%)
		Glutamate binding	690..692		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350118
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740