DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7c and Gria3

DIOPT Version :10

Sequence 1:NP_572411.1 Gene:Ir7c / 31692 FlyBaseID:FBgn0029966 Length:625 Species:Drosophila melanogaster
Sequence 2:NP_116785.2 Gene:Gria3 / 29628 RGDID:70958 Length:888 Species:Rattus norvegicus


Alignment Length:498 Identity:98/498 - (19%)
Similarity:179/498 - (35%) Gaps:130/498 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   216 MVVATFEHRPYVIIEDDPKTPGGRSIHGIEGL---IFRSLAERMNFTIKLVEQKDKNRGEILPDG 277
            :||.|....|||:.:.:.:...|...:  ||.   :...:|:.:....||         .|:.||
  Rat   419 IVVTTILESPYVMYKKNHEQLEGNERY--EGYCVDLAYEIAKHVRIKYKL---------SIVGDG 472

  Fly   278 NF----------TGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISP- 331
            .:          .|::..:|.|..::.......:..|.:::..|..:.|..|.:::.......| 
  Rat   473 KYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 537

  Fly   332 MGRLTRPFRYIIWSCILVSLIFGFVLICLLKITALPGLRNLVLGRRNRLP--------------- 381
            :.....|..|.||.||:.:.| |..::..|.....|  ....|...|..|               
  Rat   538 VFSFLDPLAYEIWMCIVFAYI-GVSVVLFLVSRFSP--YEWHLEDNNEEPRDPQSPPDPPNEFGI 599

  Fly   382 FMGMWASLLGGLAL-----YNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSL 441
            |..:|.||  |..:     .:|:....|.:..:|...|||:.::||..|...|....|.|||:| 
  Rat   600 FNSLWFSL--GAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES- 661

  Fly   442 SEVLAKDYEFRILPALRTIFKDSMPTTNF--HAVLSLEESLYRLRDEDDPGI---TVA------- 494
            :|.|||..|.    |..|:  ||..|..|  .:.:::.|.::......:|.:   |.|       
  Rat   662 AEDLAKQTEI----AYGTL--DSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR 720

  Fly   495 --------LLQPTVNQFDFRSGP-----------NKRHLTVLPDPLMTAPLTFYMRPHSYFKRRI 540
                    ||:.|:|::..:..|           :|.:....|             ..|.....:
  Rat   721 KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP-------------KGSALGTPV 772

  Fly   541 DRLIMAMMSSGIVARYR-KMYMDRIKRVSKRRNLEPK--PLSIWRLSGIFVCCAGLYLVALIVFI 602
            :..::.:...||:.:.: |.:.|:.:..:|....:.|  .||:..::|:|....|...:|::|.:
  Rat   773 NLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVAL 837

  Fly   603 LEIL--------------------------TTNHRRLRRAFNV 619
            :|..                          |.|:...|..:||
  Rat   838 IEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNV 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir7cNP_572411.1 Lig_chan-Glu_bd 225..287 CDD:214911 13/74 (18%)
Lig_chan 343..592 CDD:459656 64/302 (21%)
Gria3NP_116785.2 PBP1_iGluR_AMPA_GluR3 29..403 CDD:380610
PBP2_iGluR_AMPA 416..799 CDD:270433 83/415 (20%)
Blue background indicates that the domain is not in the aligned region.

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