Protein Alignment Ir7c and Gria2

DIOPT Version :10

• Sequence 1: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_058957.1
• Gene: Gria2 / 29627
• RGDID: 61862
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 463
• Identity: 91/463 - (19%)
• Similarity: 175/463 - (37%)
• Gaps: 96/463 - (20%)

  Fly   216 MVVATFEHRPYVIIEDDPKTPGGRSIHGIEGL---IFRSLAERMNFTIKLVEQKDKNRGEILPDG 277
            :||.|....|||:::.:.:...|...:  ||.   :...:|:...|..||.         |:.||
  Rat   416 VVVTTILESPYVMMKKNHEMLEGNERY--EGYCVDLAAEIAKHCGFKYKLT---------IVGDG 469

  Fly   278 NF----------TGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISP- 331
            .:          .|::..:|.|:.::.......:..|.:::..|..:.|..|.:::.......|
  Rat   470 KYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPG 534

  Fly   332 MGRLTRPFRYIIWSCILVSLIFGFVLICLLKITALP---GLRNLVLGRRNRLP--------FMGM 385
            :.....|..|.||.||:.:.| |..::..|.....|   .......||..:..        |..:
  Rat   535 VFSFLDPLAYEIWMCIVFAYI-GVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSL 598

  Fly   386 WASLLGGLAL-----YNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVL 445
            |.||  |..:     .:|:....|.:..:|...|||:.::||..|...|....|.|||:| :|.|
  Rat   599 WFSL--GAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDL 660

  Fly   446 AKDYE--------------FR-----ILPALRTIFKDSMPTTNFHAVLSLEESLYRLRDEDDPGI 491
            :|..|              ||     :...:.|..:.:.|:.   .|.:..|.:.|:|  ...|.
  Rat   661 SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV---FVRTTAEGVARVR--KSKGK 720

  Fly   492 TVALLQPTVNQFDFRSGP-----------NKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIM 545
            ...||:.|:|::..:..|           :|.:....|             ..|.....::..::
  Rat   721 YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATP-------------KGSSLGTPVNLAVL 772

  Fly   546 AMMSSGIVARYR-KMYMDRIKRVSKRRNLEPK--PLSIWRLSGIFVCCAGLYLVALIVFILEILT 607
            .:...|::.:.: |.:.|:.:..:|....:.|  .||:..::|:|....|...:|::|.::|...
  Rat   773 KLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 837

  Fly   608 TNHRRLRR 615
            .:....:|
  Rat   838 KSRAEAKR 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	14/74 (19%)
		Lig_chan	343..592	CDD:459656	60/297 (20%)
Gria2	NP_058957.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612
		PBP2_iGluR_AMPA	413..794	CDD:270433	80/410 (20%)
		Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133	867..877