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Protein Alignment Ir7c and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	678	Identity:	135/678 - (19%)
Similarity:	232/678 - (34%)	Gaps:	198/678 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 SGLTGRPIAIWFLDSLRSYFRLEMYLNQL-----------------GSPYKRNGFFLVIYTGLED 132
            :||||... :||           |...||                 |:|... |.|.|...|..|
Human   263 AGLTGSGY-VWF-----------MVGPQLAGGGGSGAPGEPPLLPGGAPLPA-GLFAVRSAGWRD 314

  Fly   133 QPMESLKIMFRRLLNMYVLNVNVF------LQRDGTVHLYTYYPYGPHHCQS--------SLPVY 183
            .       :.||:    ...|.|.      |.||     |.:.|...|.|::        ||..|
Human   315 D-------LARRV----AAGVAVVARGAQALLRD-----YGFLPELGHDCRAQNRTHRGESLHRY 363

  Fly   184 YTAF----QDLAAPANGFGLTKPLFPRKLTNMHGCEMV--------------------------- 217
            :...    :|.:...:||.:...|....||.....|:|
Human   364 FMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDD 428

  Fly   218 -----VATFEHRPYVIIE----------------------------DDPKTPGGRSIHGIEGLIF 249
                 |||.|.||:||:|                            |.|: |..|...|....|.
Human   429 TQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPR-PEKRCCKGFCIDIL 492

  Fly   250 RSLAERMNFTIKLVEQKDKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSY 314
            :.||..:.|:..|....:...|:.: ||.:.|::..:.....::.......::.||:::..|..:
Human   493 KRLAHTIGFSYDLYLVTNGKHGKKI-DGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPF 556

  Fly   315 TSFPI-VLVVPSGGSISPMGRLTRPFRYIIW-----SCILVSLIFGFVLICL--------LKITA 365
            ....| |:|..|.|::||...| .|:...:|     .|:.|..:..|:...|        |....
Human   557 VETGISVMVARSNGTVSPSAFL-EPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGK 620

  Fly   366 LPGLRNLVLGRRNRLPFMGMWASLL-GGLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLL 429
            .||.....:|:...|    :||.:. ..:.:.||:...::.::::|....:|..|:||..|...:
Human   621 RPGGSTFTIGKSIWL----LWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFM 681

  Fly   430 QDVEMRSPIKSLSEVLAKDYEFRILPALRTIFKDSMPTTNFHAVL--SLEESL---------YRL 483
            ...|....:..||     |.:|: .|      ::..|...|..|.  |.|:::         |.:
Human   682 IQEEYVDTVSGLS-----DRKFQ-RP------QEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMV 734

  Fly   484 RDEDDPGITVALLQPTVNQFD------------FRSGPNKRHLTVLPDPLM-TAPLTFYMRPHSY 535
            | .:.|.:..||.|....:.|            .|.....:.:|:....:. |......:...|.
Human   735 R-YNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSR 798

  Fly   536 FKRRIDRLIMAMMSSGIVARYRKMYM------DRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLY 594
            :||.||..::..:....:....::::      |:|:.:|.:       |.|..::|:|.......
Human   799 WKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSK-------LDIDNMAGVFYMLLVAM 856

  Fly   595 LVALIVFILEILTTNHRRLRRAFNVINR 622
            .::|:||..|.|.  :.|||......:|
Human   857 GLSLLVFAWEHLV--YWRLRHCLGPTHR 882

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.