DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and GRIN2C

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_016880033.1	Gene:	GRIN2C / 2905	HGNCID:	4587	Length:	1337	Species:	Homo sapiens

Alignment Length:	739	Identity:	149/739 - (20%)
Similarity:	258/739 - (34%)	Gaps:	230/739 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DLIDAALGRSSGTGRIQFLL--------------EDDRVEMTET--------------------D 78
            |::...||......|.|.||              |:..|...|.                    .
Human   272 DVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGS 336

  Fly    79 TDPPP---PSGLTGRPIAIWFLDSLRSYFRLEMYLNQLG--SPYKRNGFFLV------IYTGLED 132
            ||.||   |.||.......|.| |||...|..:.:..||  |.::::|....      ::.|...
Human   337 TDAPPATFPVGLISVVTESWRL-SLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVS 400

  Fly   133 QPMESLKIMFRRLLNM-------------YVLN---VNVFLQRDGTVH-------------LYTY 168
            ...|:   .:|.|||:             |::.   |.:.|.|    |             ||..
Human   401 PAREA---FYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNR----HRLWEMVGRWEHGVLYMK 458

  Fly   169 YPYGPHHCQSSLPVYYTAFQDLAAPANGFGLTKPLFPRKLTNMHGCEMVVATFEHRPYVIIED-D 232
            ||..|.:..|..||                         :.:.|   :.|||.|.||:||:|. |
Human   459 YPVWPRYSASLQPV-------------------------VDSRH---LTVATLEERPFVIVESPD 495

  Fly   233 PKTPG---------GRSIHGI-------------EGL---IFRSLAERMNFTIKLVEQKDKNRGE 272
            |.|.|         .:|.|..             :|.   |.:.||..:.|:..|....:...|:
Human   496 PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGK 560

  Fly   273 ILPDGNFTGILKMMVDGEV-----NLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVVPSGGSISP 331
                 ...|:...|: |||     ::.......::.||:::..|..:....| |:|..|.|::||
Human   561 -----RVRGVWNGMI-GEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP 619

  Fly   332 MGRLTRPFRYIIW-----SCILVSLIFGFVLICLLKITALPGLRNLVLGRRNRLPFMG------- 384
            ...| .|:...:|     .|:.|..|..|:......::.   .:||..|:::..|...
Human   620 SAFL-EPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSY---NQNLTRGKKSGGPAFTIGKSVWL 680

  Fly   385 MWASLL-GGLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSE----- 443
            :||.:. ..:.:.||:...::.::::|....:|..|:||..|...:...:....:..||:
Human   681 LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLH 745

  Fly   444 ------------VLAKDY-----------EFRILP------ALRTIFKDSMPTTNFHAV----LS 475
                        ....||           .|..:|      .:|:.::| |.|   |.|    .|
Human   746 LENTGVAWTAFKTFCSDYFQRPQDQYPPFRFGTVPNGSTERNIRSNYRD-MHT---HMVKFNQRS 806

  Fly   476 LEESLYRLRDEDDPGITVALLQPTVNQFD----------FRSGPNK--RHLTVLPDPLM-TAPLT 527
            :|::|..|:...:       .||...:.|          :.:|.::  :.:|:....:. |....
Human   807 VEDALTSLKMGSE-------AQPVPRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYG 864

  Fly   528 FYMRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAG 592
            ..|:..|::||.||..::..:..|...:...:::..|.:..|...:..| |.|..::|:|.....
Human   865 IAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSK-LDIDNMAGVFYMLLV 928

  Fly   593 LYLVALIVFILEILTTNHRRLRRA 616
            ...:||:||..|.|.  :.:||.:
Human   929 AMGLALLVFAWEHLV--YWKLRHS 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/87 (21%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	55/313 (18%)
GRIN2C	XP_016880033.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740