DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7c and GRIN2B

DIOPT Version :10

Sequence 1:NP_572411.1 Gene:Ir7c / 31692 FlyBaseID:FBgn0029966 Length:625 Species:Drosophila melanogaster
Sequence 2:NP_000825.2 Gene:GRIN2B / 2904 HGNCID:4586 Length:1484 Species:Homo sapiens


Alignment Length:645 Identity:123/645 - (19%)
Similarity:224/645 - (34%) Gaps:182/645 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 ETDTDPPP-PSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLED------- 132
            :|||.|.. |:||.......|                ..|.|.:......:|.|...|       
Human   265 DTDTVPAEFPTGLISVSYDEW----------------DYGLPARVRDGIAIITTAASDMLSEHSF 313

  Fly   133 --QPMESL------KIMFRRLLNMYVLNV-----NVFLQRDGTVHLYTYYP-------------- 170
              :|..|.      :|....:||.|::||     |:....||    |..:|              
Human   314 IPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDG----YQMHPKLVIILLNKERKWE 374

  Fly   171 -YGPHHCQSSLPVYYTAFQDLAAPANGFGLTKPLFPRKLTNMHGCE---MVVATFEHRPYVIIED 231
             .|....:|....||                  ::||........|   :.:.|.|..|:||:|.
Human   375 RVGKWKDKSLQMKYY------------------VWPRMCPETEEQEDDHLSIVTLEEAPFVIVES 421

  Fly   232 -DP--------------------KT---PG--GRSIHGIEGLIFRSLAERMNFTIKLVEQKDKNR 270
             ||                    ||   ||  .:...|....|.:.:::.:.||..|....:...
Human   422 VDPLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKH 486

  Fly   271 GEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVVPSGGSISPMGR 334
            |:.: :|.:.|::..:|.....:.......::.||:::..|..:....| |:|..|.|::||...
Human   487 GKKI-NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAF 550

  Fly   335 LTRPFRYIIWSCILVSLIFGFVLICLLKITAL--------------------PGLRNLVLGRRNR 379
            | .||...:|       :..||::.::...|:                    ||..:..:|:   
Human   551 L-EPFSADVW-------VMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGK--- 604

  Fly   380 LPFMGMWASLLGGLA------LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPI 438
                .:|  ||.||.      :.||:...::.::.:|....:|..|:||..|...:...|....:
Human   605 ----AIW--LLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQV 663

  Fly   439 KSLSEV-------LAKDYEFRILPALRTIFKDSMPTTNFHAVLSLEESLYRLRDEDDPGITVALL 496
            ..||:.       .:..:.|..:|...|    .....|.:|.:......:..|..||     |||
Human   664 SGLSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMGKFNQRGVDD-----ALL 719

  Fly   497 QPTVNQFD----------FRSGPNK--RHLTVLPDPLMTAPLTFY---MRPHSYFKRRIDRLIMA 546
            .....:.|          :.:|.::  :.:|:....:..:  |.|   ::..|.:||::|..|:.
Human   720 SLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAS--TGYGIAIQKDSGWKRQVDLAILQ 782

  Fly   547 MMSSGIVARYRKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEIL 606
            :...|.:.....:::..|.. :::..:....|.|..::|:|........::||.||.|.|
Human   783 LFGDGEMEELEALWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHL 841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir7cNP_572411.1 Lig_chan-Glu_bd 225..287 CDD:214911 18/87 (21%)
Lig_chan 343..592 CDD:459656 50/296 (17%)
GRIN2BNP_000825.2 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601 28/142 (20%)
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 80/429 (19%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94 604..623 5/27 (19%)
NMDAR2_C 840..1484 CDD:463148 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1074..1097
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1194
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1301
Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097 1292..1304
PDZ-binding. /evidence=ECO:0000250 1482..1484
Blue background indicates that the domain is not in the aligned region.

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