DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and GRIN2A

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_016878661.1	Gene:	GRIN2A / 2903	HGNCID:	4585	Length:	1516	Species:	Homo sapiens

Alignment Length:	710	Identity:	142/710 - (20%)
Similarity:	262/710 - (36%)	Gaps:	167/710 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 WAIDNYYGMATSTPLAVVQFPTSRESRRLHNDLIDAALGRSSGTGRIQFLLEDDRV-EMTETDTD 80
            |.:.|...:.||...|..|.    :.:::|:.:|            :.:..:|:.| .::|..:
Human   250 WDMQNVITLDTSFEDAKTQV----QLKKIHSSVI------------LLYCSKDEAVLILSEARS- 297

  Fly    81 PPPPSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLEDQPMESLKIMFRRL 145
                .||||... .|.:.||.| ...|:...:..|     |...|.|    |....||:...|..
Human   298 ----LGLTGYDF-FWIVPSLVS-GNTELIPKEFPS-----GLISVSY----DDWDYSLEARVRDG 347

  Fly   146 LNMYVLNVNVFLQRDGTVHLYTYYP------YG-------PHHCQSSLPVYYT-AFQDLAAPANG 196
            :.:.....:..|::      ::|.|      ||       |.|......|..| ..:||:....|
Human   348 IGILTTAASSMLEK------FSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEG 406

  Fly   197 F----------------------------GLTKPLFPRKLTNMHGCE-----MVVATFEHRPYVI 228
            :                            .|...::|| ..:...||     :.:.|.|..|:||
Human   407 YQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPR-YKSFSDCEPDDNHLSIVTLEEAPFVI 470

  Fly   229 IED-DPKT--------PGGRSI----HGIEGL------------IFRSLAERMNFTIKLVEQKDK 268
            :|| ||.|        |..:.:    ...||:            |.:.|:..:.||..|....:.
Human   471 VEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG 535

  Fly   269 NRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVVPSGGSISPM 332
            ..|:.: :..:.|::..:|.....:.......::.||:::..|..:....| |:|..|.|::||.
Human   536 KHGKKV-NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 599

  Fly   333 GRLTRPFRYIIWSCILVS-LIFGFVLICLLKITALPGL-RNLVLGRRNRLPFM----GMWASLLG 391
            ..| .||...:|..:.|. ||...:.:.:.:..:..|. |||..|:....|..    .:|  ||.
Human   600 AFL-EPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIW--LLW 661

  Fly   392 GLA------LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVLAKDYE 450
            ||.      :.||:...::.::.:|....:|..|:||..|...:...|....:..||     |.:
Human   662 GLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLS-----DKK 721

  Fly   451 FRILPALRTIFKDSMPTTNFHAVL--SLEESLYR--------LRDEDDPGITVALLQPTVNQFD- 504
            |: .|      .|..|...|..|.  |.|.::..        :...:..|:..||:.....:.|
Human   722 FQ-RP------HDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDA 779

  Fly   505 ---------FRSGPNK--RHLTVLPDPLM-TAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARYR 557
                     :::|.::  :.:|:....:. |......::..|.:||:||..::..:..|.:....
Human   780 FIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELE 844

  Fly   558 KMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEILTTNHRRLRRAF 617
            .:::..|.. :::..:....|.|..::|:|...|....::||.||.|.|.  :.:||..|
Human   845 TLWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF--YWKLRFCF 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/86 (21%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	54/284 (19%)
GRIN2A	XP_016878661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740