DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7c and GRIK5

DIOPT Version :9

Sequence 1:NP_001245572.1 Gene:Ir7c / 31692 FlyBaseID:FBgn0029966 Length:625 Species:Drosophila melanogaster
Sequence 2:XP_011525167.1 Gene:GRIK5 / 2901 HGNCID:4583 Length:982 Species:Homo sapiens


Alignment Length:445 Identity:96/445 - (21%)
Similarity:179/445 - (40%) Gaps:77/445 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   216 MVVATFEHRPYVIIEDDPKTPGGRSIHG---IEGL---IFRSLAERMNFTIKLVEQKDKNRGEIL 274
            :||.|....|||:     :.|..:::.|   .||.   :.|.|||.:.|..:|...:|...|...
Human   417 LVVTTILENPYVM-----RRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPE 476

  Fly   275 PDGNFTGILKMMVDGE-VNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISPMGR---- 334
            |:|::||::..:::.: .:|....|..:..|..::..|..:.:..|.::..     ..|||    
Human   477 PNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYR-----VHMGRKPGY 536

  Fly   335 --LTRPFRYIIWSCILVSLIFGFVLICLLKITAL----------PGLR--------NLVLGRRNR 379
              ...||...:|..:|::.:   .:.|:|.:.|.          |.||        ...||....
Human   537 FSFLDPFSPAVWLFMLLAYL---AVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLW 598

  Fly   380 LP---FMGMWASLLGGLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSL 441
            .|   ||...:.::       |:....|.:..:|...|||:.::||..|...|....|..|::|.
Human   599 FPVGGFMQQGSEIM-------PRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESA 656

  Fly   442 SEVLAK-DYEFRILPA--LRTIFKDSMPTT-----NFHA-------VLSLEESLYRLRDEDDPGI 491
            .::..: :.|:..:.|  ..|.|::|...|     |:..       |.|.||.:.|:.:..    
Human   657 DDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR---- 717

  Fly   492 TVALLQPTVNQFDFRSGPNKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARY 556
            ...||:.|:|::..|...|   ||.:...|.|......|...|.|:..|...|:.:..:..:...
Human   718 YAFLLESTMNEYHRRLNCN---LTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEIL 779

  Fly   557 RKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEILTTNHR 611
            ::.:.:. .|..|..:...|.|.:..:.|||:......::|:.|.::|.:.:..|
Human   780 KRKWWEG-GRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRR 833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir7cNP_001245572.1 Lig_chan-Glu_bd 225..287 CDD:214911 19/67 (28%)
Lig_chan 343..593 CDD:278489 60/285 (21%)
GRIK5XP_011525167.1 PBP1_iGluR_Kainate_KA1_2 25..399 CDD:107389
ANF_receptor 42..379 CDD:279440
Periplasmic_Binding_Protein_Type_2 414..785 CDD:304360 85/394 (22%)
Lig_chan 546..816 CDD:278489 60/287 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156215
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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