DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and GRIK3

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	484	Identity:	117/484 - (24%)
Similarity:	194/484 - (40%)	Gaps:	97/484 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 APANGFGLTK------PLFPRKLTNMHGCEMVVATFEHRPYVIIEDDPKTPGGRSIHGIEGL--- 247
            :||:|..:|:      |.....|||.   .::|.|....|:|:.....:|..|..  ..||.
Human   409 SPADGLNITEVAKGRGPNVTDSLTNR---SLIVTTVLEEPFVMFRKSDRTLYGND--RFEGYCID 468

  Fly   248 IFRSLAERMNFT--IKLVE------QKDKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKAR 304
            :.:.||..:.|:  |:|||      |.||        |.:.|::|.::|.:.:|.......:..|
Human   469 LLKELAHILGFSYEIRLVEDGKYGAQDDK--------GQWNGMVKELIDHKADLAVAPLTITHVR 525

  Fly   305 SDLMLPSTSYTSFPIVLVV--PSGGSISPMGRLTRPFRYIIWSCILVSLIFGFVLICLLKITAL- 366
            ...:..|..:.:..:.::.  |:|.:.|....| .|....||..:|::.:   .:.|:|.:.|.
Human   526 EKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFL-NPLSPDIWMYVLLAYL---GVSCVLFVIARF 586

  Fly   367 ------------PGL----RNLVLGRRNRLPFMGMWASLLGGLALYNPQRNFARYILVMWLLQTL 415
                        ||.    .|..|  .|...| ||.:.:..|..|. |:....|.|..:|...||
Human   587 SPYEWYDAHPCNPGSEVVENNFTL--LNSFWF-GMGSLMQQGSELM-PKALSTRIIGGIWWFFTL 647

  Fly   416 ILRAAYTGQLYLLLQDVEMRSPIKSLSEVLAKD--YEFRILP--ALRTIFKDSMPTT--NFHAVL 474
            |:.::||..|...|....|.|||.|..: |||.  .|:..:.  |..|.||.|..:|  ...|.:
Human   648 IIISSYTANLAAFLTVERMESPIDSADD-LAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM 711

  Fly   475 SLEESLYRLRDEDDPGITVA-------LLQPTVNQFDFRSGPNKRHLTVLPDPL---MTAPLTFY 529
            |.:.|  .|...::.||..|       |::.|..::..:...|...:..|.|..   :..|:...
Human   712 SSKPS--ALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSP 774

  Fly   530 MRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDRIK--RVS---KRRNLEPKPLSIWRLSGIF-V 588
            .|         |::.:|::.   :....|:::.:.|  |.|   :..|.|...|.|.::.||| |
Human   775 YR---------DKITIAILQ---LQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIV 827

  Fly   589 CCAGLYLVALIV---FILEILTTNHRRLR 614
            ..|||.|..|:.   |:.::..|..|..|
Human   828 LAAGLVLSVLVAVGEFVYKLRKTAEREQR 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	19/72 (26%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	71/288 (25%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	3/7 (43%)
		ANF_receptor	55..398	CDD:279440
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	91/403 (23%)
		Lig_chan	564..832	CDD:278489	71/289 (25%)
		Glutamate binding. /evidence=ECO:0000250	690..692		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740